Anti-beta Casein 抗体 [F20.14] (ab47972)
Key features and details
- Mouse monoclonal [F20.14] to beta Casein
- Suitable for: IHC-P, IHC-Fr, WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-beta Casein antibody [F20.14]
beta Casein 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [F20.14] to beta Casein -
由来種
Mouse -
特異性
This antibody reacts with beta-casein. The reactivity with alpha-casein has not been tested.
This antibody does not react with alpha lactalbumin. This antibody can be used as an in vitro marker of terminally differentiated breast lumenal epithelial cells.
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アプリケーション
適用あり: IHC-P, IHC-Fr, WBmore details -
種交差性
交差種: Human -
免疫原
Full length protein corresponding to Human beta Casein.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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精製度
Protein A/G purified -
ポリ/モノ
モノクローナル -
クローン名
F20.14 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab47972の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
---|---|---|
IHC-P | (1) |
Use at an assay dependent concentration.
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IHC-Fr |
Use at an assay dependent concentration.
Fix with acetone. |
|
WB |
Use at an assay dependent concentration.
|
特記事項 |
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IHC-P
Use at an assay dependent concentration. |
IHC-Fr
Use at an assay dependent concentration. Fix with acetone. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Important role in determination of the surface properties of the casein micelles. -
組織特異性
Mammary gland specific. Secreted in milk. -
配列類似性
Belongs to the beta-casein family. -
翻訳後修飾
Form 1-P is phosphorylated once; half of the molecules are phosphorylated on Ser-24, half on Ser-25. -
細胞内局在
Secreted. - Information by UniProt
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参照データベース
- Entrez Gene: 1447 Human
- Omim: 115460 Human
- SwissProt: P05814 Human
- Unigene: 2242 Human
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別名
- Beta-casein antibody
- CASB antibody
- CASB_HUMAN antibody
see all
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab47972 は 4 報の論文で使用されています。
- Garner KEL et al. The Milk Protein Alpha-Casein Suppresses Triple Negative Breast Cancer Stem Cell Activity Via STAT and HIF-1alpha Signalling Pathways in Breast Cancer Cells and Fibroblasts. J Mammary Gland Biol Neoplasia 24:245-256 (2019). PubMed: 31529195
- Chew GL et al. Dynamic changes in high and low mammographic density human breast tissues maintained in murine tissue engineering chambers during various murine peripartum states and over time. Breast Cancer Res Treat 140:285-97 (2013). PubMed: 23881524
- Bonuccelli G et al. The milk protein a-casein functions as a tumor suppressor via activation of STAT1 signaling, effectively preventing breast cancer tumor growth and metastasis. Cell Cycle 11:3972-82 (2012). PubMed: 23047602
- Burchell J et al. Production and characterization of monoclonal antibodies to human casein. A monoclonal antibody that cross-reacts with casein and alpha-lactalbumin. Hybridoma 4:341-50 (1985). PubMed: 3905581