Anti-beta 2 Microglobulin 抗体 [3F9-2C2] (ab54810)
![Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)](https://www.abcam.co.jp/ps/products/54/ab54810/Images/ab54810-67864-anti-beta-2-microglobulin-antibody-immunohistochemistry.jpg "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)")
Key features and details
- Mouse monoclonal [3F9-2C2] to beta 2 Microglobulin
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG2b
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-beta 2 Microglobulin antibody [3F9-2C2]
beta 2 Microglobulin 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [3F9-2C2] to beta 2 Microglobulin -
由来種
Mouse -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein, corresponding to amino acids 1-120 of Human beta 2 Microglobulin
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特記事項
This product was changed from ascites to tissue culture supernatant on 22/03/2019. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4 -
Concentration information loading... -
精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
3F9-2C2 -
アイソタイプ
IgG2b -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab54810の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use at an assay dependent concentration. Predicted molecular weight: 14 kDa.
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| IHC-P |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
|
WB
Use at an assay dependent concentration. Predicted molecular weight: 14 kDa. |
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IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. -
関連疾患
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. -
配列類似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain. -
翻訳後修飾
Glycation of Ile-21 is observed in long-term hemodialysis patients. -
細胞内局在
Secreted. Detected in serum and urine. - Information by UniProt
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参照データベース
- Entrez Gene: 567 Human
- Omim: 109700 Human
- SwissProt: P61769 Human
- Unigene: 534255 Human
- Unigene: 702947 Human
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別名
- B2M antibody
- B2MG_HUMAN antibody
- Beta 2 microglobin antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)
beta 2 Microglobulin antibody (ab54810) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human esophagus.
This image was generated using the ascites version of the product.
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![Western blot - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)](https://www.abcam.co.jp/ps/products/54/ab54810/Images/ab54810-67863-anti-beta-2-microglobulin-antibody-western-blot.jpg)
Western blot - Anti-beta 2 Microglobulin antibody [3F9-2C2] (ab54810)beta 2 Microglobulin antibody (ab54810) at 1ug/lane + U-2 cell lysate at 25ug/lane.
This image was generated using the ascites version of the product.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (2)
ab54810 は 2 報の論文で使用されています。
- Diller M et al. The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts. Arthritis Res Ther 21:144 (2019). PubMed: 31182152
- Wang J et al. Mesenchymal Stromal Cells-Derived ß2-Microglobulin Promotes Epithelial-Mesenchymal Transition of Esophageal Squamous Cell Carcinoma Cells. Sci Rep 8:5422 (2018). PubMed: 29615660
