JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB20128

Anti-BarX2 抗体 [BAR X2 8A7/1]

Anti-BarX2 antibody [BAR X2 8A7/1]

4

(1 Review)

|

(2 Publications)

Mouse Monoclonal BARX2 antibody. Suitable for ELISA, WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Protein within Human BARX2.

別名を表示する

Homeobox protein BarH-like 2, BARX2

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

BAR X2 8A7/1

アイソタイプ

IgG1

軽鎖のタイプ

unknown

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, ICC/IF, ELISA, WB

applications

免疫原

Recombinant Protein within Human BARX2. The exact immunogen used to generate this antibody is proprietary information.

Q9UMQ3

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
style
left-column

製品の詳細

BarX2 is a tumour suppressor gene that encodes for a transcription factor known to regulate transcription of cell adhesion molecules in the mouse.
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
バッファー組成
Preservative: 0.02% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

BarX2 also known as BarH-like 2 is a transcription factor involved in gene regulation. BarX2 has an estimated mass of around 36 kDa. It initially expresses in various tissues including the central nervous system and the developing limb. BarX2 contains a homeobox domain a DNA-binding region influencing gene expression by interacting with specific DNA sequences. This capability makes it critical in transcriptional regulation involved in developmental processes.
Biological function summary

BarX2 plays a significant role in neuronal differentiation and limb patterning. It functions by controlling the expression of downstream target genes that drive cellular differentiation and growth. BarX2 does not form part of a larger complex but interacts individually with target genes in developmentally active tissues. It affects the expression patterns that lead to specific cell fates especially during embryogenesis.

Pathways

The transcription factor BarX2 integrates into critical pathways like the Wnt signaling and Notch signaling. These pathways are pivotal in regulating cell proliferation differentiation and apoptosis. BarX2 works alongside proteins like beta-catenin in Wnt signaling to influence gene expression changes important for cell fate decisions. In Notch signaling BarX2 modulates the balance between cell proliferation and differentiation essential in developing organs.

BarX2 has connections to oncogenesis and certain developmental defects. Its altered expression or mutation correlates with colorectal cancer impacting the regulation of cell proliferation and apoptosis. BarX2 interacts with proteins such as c-Myc which plays a role in promoting cellular growth and cancer development. Additionally in developmental defects aberrant BarX2 expression links to limb malformations where it influences the expression of genes controlling limb patterning and skeletal formation.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Transcription factor. Binds optimally to the DNA consensus sequence 5'-YYTAATGRTTTTY-3'. May control the expression of neural adhesion molecules such as L1 or Ng-CAM during embryonic development of both the central and peripherical nervous system. May be involved in controlling adhesive processes in keratinizing epithelia (By similarity).
See full target information BARX2
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:11974 PubMed40199990

2025

Menstrual blood serum extracellular vesicles reveal novel molecular biomarkers and potential endotypes of unexplained infertility.

Applications

Unspecified application

Species

Unspecified reactive species

Kieran Brennan,Raminta Vaiciuleviciute,Ilona Uzieliene,Jolita Pachaleva,Zaneta Kasilovskiene,Lina Piesiniene,Eiva Bernotiene,Margaret M Mc Gee

Journal of cellular physiology 234:23596-23607 PubMed31236953

2019

miR-942 promotes tumor migration, invasion, and angiogenesis by regulating EMT via BARX2 in non-small-cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fengming Yang,Chuchu Shao,Ke Wei,Xinming Jing,Zhiqiang Qin,Yuenian Shi,Yongqian Shu,Hua Shen
View all publications
style
left-column
style
left-column
style
right-column

組合せ製品

Secondary Antibodies

AB150113

Goat Anti-Mouse IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (AB150113)

  • 5
  • 15
Primary Antibodies

AB3649

Anti-Mucin 5AC antibody [45M1]

BOND RX™ Validated|Advanced Validation|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Mucin 5AC antibody [45M1] (AB3649)

  • 5
  • 8
Primary Antibodies

AB307727

Anti-ALP antibody [EPR27191-14] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ALP antibody [EPR27191-14] - BSA and Azide free (AB307727)

  • 0
  • 0
Primary Antibodies

AB212201

Anti-Human IgM antibody [EPR20731]

RabMAb|Recombinant

Flow Cytometry - Anti-Human IgM antibody [EPR20731] (AB212201)

  • 0
  • 0

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com