AB99304

Anti-ATXN2L 抗体

Name: Anti-ATXN2L 抗体 (ab99304) | Abcam
Brand: Abcam Limited
SKU: AB99304
Price: 74000 JPY
Availability: InStock

Anti-ATXN2L antibody

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(3 Publications)

Rabbit Polyclonal ATXN2L antibody. Suitable for IP, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ATXN2L aa 150-200.

別名を表示する

A2D, A2LG, A2LP, A2RP, ATXN2L, Ataxin-2-like protein, Ataxin-2 domain protein, Ataxin-2-related protein

2 Images

Unknown

Immunoprecipitation - Anti-ATXN2L antibody (AB99304)

ab99304, at 0.1 μg/ml, staining ATXN2L in HeLa whole cell lysate immunoprecipitated using ab99304 at 3 μg/mg lysate (1 mg/IP; 20% of IP loaded/lane). Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-ATXN2L antibody (ab99304)

Predicted band size: 113 kDa

false

Unknown

Western blot - Anti-ATXN2L antibody (AB99304)

All lanes:

Western blot - Anti-ATXN2L antibody (ab99304) at 0.04 µg/mL

Lane 1:

Hela whole cell lysate at 50 µg

Lane 2:

Hela whole cell lysate at 15 µg

Lane 3:

Hela whole cell lysate at 5 µg

Lane 4:

293T whole cell lysate at 50 µg

Predicted band size: 113 kDa

true

Exposure time: 30s

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IP, WB

applications

免疫原

Synthetic Peptide within Human ATXN2L aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

Q8WWM7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Mouse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Elephant": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Guinea pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rabbit": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ATXN2L also known as ataxin-2-like protein is a protein encoded by the ATXN2L gene. This protein has a mass of approximately 130 kilodaltons. It is widely expressed in various tissues including the brain and liver. Structurally ATXN2L contains multiple HEAT repeat sequences which facilitate its role in protein-protein interactions. The protein localizes primarily to the cytoplasm and is involved in the modulation of RNA metabolism.

Biological function summary

The ATXN2L protein interacts with other cellular components to influence mRNA stability and translation. It forms part of RNA granules structures that play a significant role in the post-transcriptional regulation of gene expression. Through these interactions ATXN2L can affect the cellular response to stress by managing the translation of stress response genes. Its function is critical in maintaining proper RNA homeostasis under various cellular conditions.

Pathways

Various interacting partners connect ATXN2L to fundamental biological processes. It is involved in the insulin signaling pathway which is important for energy balance and cellular growth. Additionally it participates in stress granule assembly involving other proteins such as G3BP1 and EIF2α. These pathways highlight the protein's importance in cellular stress responses and metabolism regulation.

Disruptions in ATXN2L function are associated with neurodegenerative conditions and metabolic syndrome. Mutations or altered expressions may link to amyotrophic lateral sclerosis (ALS) where it interacts with proteins like TDP-43 influencing disease progression. Furthermore its role in the insulin signaling pathway connects ATXN2L to type 2 diabetes implicating it in the development of insulin resistance.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Involved in the regulation of stress granule and P-body formation.

See full target information ATXN2L

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Theranostics 15:1966-1986 PubMed39897553

2025

TBX3 shapes an immunosuppressive microenvironment and induces immunotherapy resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi Liu,Chunyu Zhang,Jiatong Xiao,Yunbo He,Haisu Liang,Jinliang Huang,Zhiyong Cai,Zhenglin Yi,Mingfeng Chen,Yixiao Li,Jun Zhang,Fenglian Liu,Peng Ren,Huihuang Li,Jinbo Chen,Benyi Fan,Jiao Hu,Xiongbing Zu,Dingshan Deng

Cell reports 42:112419 PubMed37074914

2023

Time-dependent regulation of cytokine production by RNA binding proteins defines T cell effector function.

Applications

Unspecified application

Species

Unspecified reactive species

Branka Popović,Benoît P Nicolet,Aurélie Guislain,Sander Engels,Anouk P Jurgens,Natali Paravinja,Julian J Freen-van Heeren,Floris P J van Alphen,Maartje van den Biggelaar,Fiamma Salerno,Monika C Wolkers

Journal of thrombosis and haemostasis : JTH 21:522-533 PubMed36696182

2023

Novel genetic regulators of fibrinogen synthesis identified by an in vitro experimental platform.

Applications

Unspecified application

Species

Unspecified reactive species

Dre'Von A Dobson,Lori A Holle,Feng-Chang Lin,Jennifer E Huffman,James P Luyendyk,Matthew J Flick,Nicholas L Smith,Paul S de Vries,Alanna C Morrison,Alisa S Wolberg

View all publications

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Abcam product promise

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Anti-ATXN2L 抗体

Anti-ATXN2L antibody

Immunoprecipitation - Anti-ATXN2L antibody (AB99304)

Western blot - Anti-ATXN2L antibody (AB99304)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise