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AB129742

Anti-ATP5G3 抗体

Anti-ATP5G3 antibody

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(2 Publications)

Rabbit Polyclonal ATP5G3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ATP5MC3.

別名を表示する

ATP5G3, ATP5MC3, ATP synthase lipid-binding protein, ATP synthase membrane subunit c locus 3, ATP synthase proteolipid P3, ATP synthase proton-transporting mitochondrial F(0) complex subunit C3, ATPase protein 9, ATPase subunit c

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP5G3 antibody (AB129742)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP5G3 antibody (AB129742)

ab129742, at 1/50 dilution, staining ATP5G3 in paraffin-embedded Human pancreas tissue by Immunohistochemistry in the presence (right panel) or absence (left panel) of immunizing peptide.

Immunocytochemistry/ Immunofluorescence - Anti-ATP5G3 antibody (AB129742)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ATP5G3 antibody (AB129742)

ab129742, at 1/100 dilution, staining ATP5G3 in A549 cells by Immunofluorescence in the presence (right panel) or absence (left panel) of immunizing peptide.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, ICC/IF

applications

免疫原

Synthetic Peptide within Human ATP5MC3. The exact immunogen used to generate this antibody is proprietary information.

P48201

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Stable for 12 months at -20°C

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ATP5G3 also known as ATP synthase F0 subunit C3 or mitochondrial ATP synthase membrane subunit C locus 3 is a component of the ATP synthase complex. This protein has an approximate mass of 8.2 kDa. It is expressed in many tissues with high levels observed in metabolically active organs such as the heart liver and skeletal muscle. The primary role of ATP5G3 involves contributing to the formation of the proton channel in the mitochondrial membrane which is essential for ATP synthesis during cellular respiration.
Biological function summary

ATP5G3 plays an important role in the mitochondrial ATP synthase complex also referred to as Complex V part of the electron transport chain. This complex catalyzes the conversion of ADP and inorganic phosphate into ATP using the proton gradient established by the complexes I-IV. ATP5G3 through its mechanical function helps maintain the efficiency of ATP production within cells. Its operation is important for cellular energy supply supporting processes like muscle contraction and biosynthetic reactions.

Pathways

ATP5G3 integrates into the oxidative phosphorylation pathway where it interacts with other subunits of the ATP synthase complex to ensure ATP synthesis. This pathway coordinates with the citric acid cycle (Krebs cycle) which generates the electrons used to establish the proton gradient necessary for ATP production. Proteins such as cytochrome c and NADH dehydrogenase (Complex I) connect with ATP5G3 through their roles in the electron transport chain creating a streamlined flow of electron transfer and energy conversion.

Dysregulation of ATP5G3 can contribute to conditions like mitochondrial myopathy and Leigh syndrome where impaired ATP synthesis leads to reduced cellular energy output. Mitochondrial dysfunctions with ATP5G3 at the center often relate to oxidative stress and metabolic imbalances. Connections with cytochrome c and other electron transport components illustrate the broader impact of ATP5G3 disruptions leading to the progression of these diseases through compromised cellular respiration and energy homeostasis.

製品プロトコール

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ターゲットの情報

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
See full target information ATP5MC3

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular biosciences 8:793732 PubMed35320929

2022

Systematic Analysis and Validation of the Prognosis, Immunological Role and Biology Function of the Ferroptosis-Related lncRNA GSEC/miRNA-101-3p/CISD1 Axis in Lung Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiulin Jiang,Yixiao Yuan,Lin Tang,Juan Wang,Dahang Zhang,Lincan Duan

ACS pharmacology & translational science 2:453-467 PubMed32259077

2019

Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies.

Applications

Unspecified application

Species

Unspecified reactive species

Jon K Obst,Jun Wang,Kunzhong Jian,David E Williams,Amy H Tien,Nasrin Mawji,Teresa Tam,Yu Chi Yang,Raymond J Andersen,Kim N Chi,Bruce Montgomery,Marianne D Sadar
View all publications

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