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AB81292

Anti-ATM (phospho S1981) 抗体 [EP1890Y]

Anti-ATM (phospho S1981) antibody [EP1890Y]

5

(18 Reviews)

|

(328 Publications)

Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) is a rabbit monoclonal antibody detecting ATM in Western Blot, Flow Cytometry (Intra), Flow Cytometry, IP, IHC-P, Dot Blot. Suitable for Human.

- Biophysical QC for unrivalled batch-batch consistency
- Over 320 publications
- Trusted since 2009

別名を表示する

Serine-protein kinase ATM, Ataxia telangiectasia mutated, A-T mutated, ATM

10 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human hepatocellular carcinoma tissue labelling ATM (phospho S1981) with purified ab81292 at 1/70. Heat mediated antigen retrieval was performed using Tris/EDTA buffer pH 9. ab97051, an HRP-conjugated goat anti-rabbit IgG (H+L) was used as the secondary antibody (1/500).

Negative control using PBS instead of primary antibody.

Counterstained with hematoxylin.

Western blot - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • WB

Unknown

Western blot - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Blocking and dilution buffer : 5% NFDM/TBST.

All lanes:

Western blot - Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) at 1/50000 dilution

Lane 1:

HEK-293 (Human epithelial cell line from embryonic kidney) cell lysate, untreated at 10 µg

Lane 2:

HEK-293 cell lysate, treated with Doxorubicin at 10 µg

Secondary

All lanes:

Peroxidase conjugated goat anti-rabbit IgG (H+L) at 1/1000 dilution

Predicted band size: 351 kDa

Observed band size: 370 kDa

false

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human endometrial carcinoma tissue labeling ATM with unpurified ab81292.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Flow Cytometry (Intracellular) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • Flow Cyt (Intra)

Unknown

Flow Cytometry (Intracellular) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Intracellular Flow Cytometry analysis of HepG2 (Human hepatocellular carcinoma) cells labeling ATM (phospho S1981) with purified ab81292 at 1/60 dilution (10μg/mL) (red).

Cells were fixed with 4% paraformaldehyde and permeabilized with 90% methanol. A Goat anti rabbit IgG (Alexa Fluorr®488) at 1/2000 dilution was used as the secondary antibody. Rabbit monoclonal IgG (Black) was used as the isotype control, cells without incubation with primary antibody and secondary antibody (Blue) was used as the unlabeled control.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of normal human tonsil tissue labeling ATM with unpurified ab81292.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human gastric carcinoma tissue labeling ATM with unpurified ab81292 at a 1/100 dilution.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labeling ATM with unpurified ab81292.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human cervical carcinoma tissue labeling ATM with unpurified ab81292.

Perform heat mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.

Immunoprecipitation - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • IP

Unknown

Immunoprecipitation - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

ATM was immunoprecipitated from HEK-293 (Human embryonic kidney epithelial cell) treated with Doxorubicin whole cell lysate with ab81292 at 1/30 dilution (5 μg in 1 mg lysates). Western blot was performed from the immunoprecipitate using ab81292 at 1/2000 dilution. An anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG was used as secondary antibody at 1/1500 dilution.
Lane 1 : HEK-293 treated with Doxorubicin whole cell lysate 10 μg (Input).
Lane 2 : ab81292 IP in HEK-293 treated with Doxorubicin whole cell lysate.
Lane 3 : Rabbit monoclonal IgG (ab172730) instead of ab81292 in HEK-293 treated with Doxorubicin whole cell lysate.
Blocking/Dilution buffer : 5% NFDM/TBST.
Exposure time : 3 minutes.

All lanes:

Immunoprecipitation - Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292)

Predicted band size: 351 kDa

false

Dot Blot - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)
  • Dot

Unknown

Dot Blot - Anti-ATM (phospho S1981) antibody [EP1890Y] (AB81292)

Dot blot analysis of ATM peptides using ab81292 at 1/000 dilution followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated secondary antibody (ab97051) at 1/100,000 dilution.

Blocking and diluting buffer was 5% NFDM/TBST, exposure time 3 minutes.

Lane 1 : ATM (pS1981) phospho peptide

Lane 2 : ATM non-phospho peptide

Lane 3 : ATM (pS428) phospho peptide

関連する標識済み抗体及び組成の異なる製品 (10)

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  • 660 APC

    APC Anti-ATM (phospho S1981) antibody [EP1890Y]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-ATM (phospho S1981) antibody [EP1890Y]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-ATM (phospho S1981) antibody [EP1890Y]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-ATM (phospho S1981) antibody [EP1890Y]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-ATM (phospho S1981) antibody [EP1890Y]

  • HRP

    HRP Anti-ATM (phospho S1981) antibody [EP1890Y]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-ATM (phospho S1981) antibody [EP1890Y]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-ATM (phospho S1981) antibody [EP1890Y]

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EP1890Y

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, Dot, IP, Flow Cyt (Intra), IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCytIntra" : {"fullname" : "Flow Cytometry (Intracellular)", "shortname":"Flow Cyt (Intra)"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "1/30 - 1/40", "IP-species-notes": "<p></p>", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/50000", "WB-species-notes": "<p><strong>We highly recommend using a positive control such as HEK293 cells treated with 10uM doxorubicin for 24 hours.</strong></p>", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "1/70 - 1/250", "ICCIF-species-notes": "<p></p>", "FlowCytIntra-species-checked": "testedAndGuaranteed", "FlowCytIntra-species-dilution-info": "1/60", "FlowCytIntra-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/70 - 1/250", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol." }, "Synthetic peptide": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "Dot-species-checked": "testedAndGuaranteed", "Dot-species-dilution-info": "1/100000", "Dot-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "FlowCytIntra-species-checked": "notRecommended", "FlowCytIntra-species-dilution-info": "", "FlowCytIntra-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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AB279739

Phospho-ATM (S1981) ELISA Kit

0

0 Reviews

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製品の詳細

Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) was developed by Abcam using patented rabbit monoclonal antibody technology and is validated for use in Dot blot, Flow Cyt (Intra), IHC-P, IP, WB in human samples.

Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) has been cited over 328 times in peer reviewed journals and is trusted by the scientific community.

Abcam's high quality manufacturing and validation processes ensure Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) has high sensitivity and specificity alongside high lot-to-lot consistency and reproducibility.

Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) has 17 independent reviews from customers.

Anti-ATM (phospho S1981) antibody [EP1890Y] (ab81292) specifically detects ATM Phospho-S1981 (UniProt ID: Q13315; Molecular weight: 351kDa) and is sold in 100 µL and 1 mL selling sizes.

Conjugation-ready, carrier free format available for antibody clone EP1890Y - ab208775.

Antibody clone EP1890Y is also available pre-conjugated to a variety of labels for your convenience - PE, APC, HRP, Alkaline Phosphatase, Alexa Fluor® 488, Alexa Fluor® 647, Alexa Fluor® 594, Alexa Fluor® 555 (ab305629, ab305630, ab305631, ab308654, ab309629, ab309995, ab310358, ab311880).

ATM is a significant target in oncology due to its role in DNA repair and maintaining genomic stability. Mutations in the ATM gene can lead to defective DNA repair, resulting in increased cancer risk and chemotherapy resistance.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Species reactivity
Rat: We have preliminary internal testing data to indicate this antibody may not react with this species.
Please contact us for more information.

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ATM also known as Ataxia Telangiectasia Mutated is a protein kinase with a molecular weight of approximately 370 kDa. ATM protein primarily resides in the cell nucleus and functions as a critical regulator of the cell cycle. It plays a significant role in the detection of DNA damage and initiation of repair processes. As part of its mechanical functions ATM phosphorylates serine and threonine residues on various substrates most notably in response to double-strand breaks in DNA. This activity is important for maintaining genomic stability.
Biological function summary

ATM acts as a coordinator in cellular response to DNA damage highly interacting with multiple components of the DNA repair machinery. It forms a complex with proteins like NBS1 and MRN complex facilitating repair by recruiting and activating other proteins involved in homologous recombination and non-homologous end joining pathways. ATM also modulates p53 activity a primary response factor in cellular stress management linking ATM to control of cell cycle arrest and apoptosis. This positions ATM as an integral part of maintaining cellular integrity in face of genomic insult.

Pathways

ATM integrates neatly within the DNA damage response and cell cycle control pathways. ATM's operative relationship with the MRN complex and its role in the PI3K-related protein kinase family helps initiate appropriate repair processes upon DNA damage detection. Additionally ATM regulates the activity of proteins such as Chk2 which further propagates signals to p53 influencing decisions between cell cycle arrest and apoptosis. These interactions link ATM closely to essential processes like DNA repair and cell survival highlighting its role in genomic maintenance.

ATM mutations or dysregulation leads to Ataxia Telangiectasia an autosomal recessive disorder characterized by neurodegeneration immune deficiencies and cancer predisposition. ATM dysfunction also connects to cancer development particularly breast cancer where it transmits signals involving BRCA1 contributing to DNA repair through homologous recombination. Understanding ATM dynamics and related pathways has important implications for developing therapeutic strategies to manage or mitigate effects associated with its dysfunction.

製品プロトコール

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ターゲットの情報

Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor (PubMed : 10550055, PubMed : 10839545, PubMed : 10910365, PubMed : 12556884, PubMed : 14871926, PubMed : 15064416, PubMed : 15448695, PubMed : 15456891, PubMed : 15790808, PubMed : 15916964, PubMed : 17923702, PubMed : 21757780, PubMed : 24534091, PubMed : 35076389, PubMed : 9733514). Recognizes the substrate consensus sequence [ST]-Q (PubMed : 10550055, PubMed : 10839545, PubMed : 10910365, PubMed : 12556884, PubMed : 14871926, PubMed : 15448695, PubMed : 15456891, PubMed : 15916964, PubMed : 17923702, PubMed : 24534091, PubMed : 9733514). Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism (By similarity). Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FBXW7, FANCD2, NFKBIA, BRCA1, CREBBP/CBP, RBBP8/CTIP, MRE11, nibrin (NBN), RAD50, RAD17, PELI1, TERF1, UFL1, RAD9, UBQLN4 and DCLRE1C (PubMed : 10550055, PubMed : 10766245, PubMed : 10802669, PubMed : 10839545, PubMed : 10910365, PubMed : 10973490, PubMed : 11375976, PubMed : 12086603, PubMed : 15456891, PubMed : 19965871, PubMed : 21757780, PubMed : 24534091, PubMed : 26240375, PubMed : 26774286, PubMed : 30612738, PubMed : 30886146, PubMed : 30952868, PubMed : 38128537, PubMed : 9733515, PubMed : 9843217). May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Plays a role in replication-dependent histone mRNA degradation. Binds DNA ends. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation (PubMed : 19965871). Phosphorylates ATF2 which stimulates its function in DNA damage response (PubMed : 15916964). Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks (PubMed : 29203878). Phosphorylates TTC5/STRAP at 'Ser-203' in the cytoplasm in response to DNA damage, which promotes TTC5/STRAP nuclear localization (PubMed : 15448695). Also involved in pexophagy by mediating phosphorylation of PEX5 : translocated to peroxisomes in response to reactive oxygen species (ROS), and catalyzes phosphorylation of PEX5, promoting PEX5 ubiquitination and induction of pexophagy (PubMed : 26344566).
See full target information ATM phospho S1981

文献 (328)

Recent publications for all applications. Explore the full list and refine your search

Science advances 9:eadi6681 PubMed38055811

2023

RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons.

Applications

Unspecified application

Species

Unspecified reactive species

Huimin Zhang,Yun Xiong,Yilun Sun,Jeong-Min Park,Dan Su,Xu Feng,Sarah Keast,Mengfan Tang,Min Huang,Chao Wang,Mrinal Srivastava,Chang Yang,Dandan Zhu,Zhen Chen,Siting Li,Ling Yin,Yves Pommier,Junjie Chen

Scientific reports 13:21211 PubMed38040841

2023

Differential effects of pesticides on dioxin receptor signaling and p53 activation.

Applications

Unspecified application

Species

Unspecified reactive species

Myriam Fauteux,Nadia Côté,Sandra Bergeron,Alexandre Maréchal,Luc Gaudreau

Cancer & metabolism 11:20 PubMed37932830

2023

ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Cristina Terlizzi,Viviana De Rosa,Francesca Iommelli,Antonio Pezone,Giovanna G Altobelli,Maurizio Maddalena,Jelena Dimitrov,Caterina De Rosa,Carminia Maria Della Corte,Vittorio Enrico Avvedimento,Silvana Del Vecchio

Nature communications 14:7069 PubMed37923710

2023

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Lin-Lin Zhou,Tao Zhang,Yun Xue,Chuan Yue,Yihui Pan,Pengyu Wang,Teng Yang,Meixia Li,Hu Zhou,Kan Ding,Jianhua Gan,Hongbin Ji,Cai-Guang Yang

Open medicine (Warsaw, Poland) 18:20230757 PubMed37840753

2023

Activation of UBEC2 by transcription factor MYBL2 affects DNA damage and promotes gastric cancer progression and cisplatin resistance.

Applications

Unspecified application

Species

Unspecified reactive species

Jiegen Long,Bin Zhu,Tao Tian,Linfei Ren,Yong Tao,Haitao Zhu,Dengwei Li,Yonghong Xu

Signal transduction and targeted therapy 8:366 PubMed37743418

2023

Non-small cell lung cancers (NSCLCs) oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Bopei Cui,Lifang Song,Qian Wang,Kelei Li,Qian He,Xing Wu,Fan Gao,Mingchen Liu,Chaoqiang An,Qiushuang Gao,Chaoying Hu,Xiaotian Hao,Fangyu Dong,Jiuyue Zhou,Dong Liu,Ziyang Song,Xujia Yan,Jialu Zhang,Yu Bai,Qunying Mao,Xiaoming Yang,Zhenglun Liang

BMC cancer 23:835 PubMed37674118

2023

Reduced expression of phosphorylated ataxia-telangiectasia mutated gene is related to poor prognosis and gemcitabine chemoresistance in pancreatic cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jingyu Xun,Hideo Ohtsuka,Katsuya Hirose,Daisuke Douchi,Shun Nakayama,Masaharu Ishida,Takayuki Miura,Kyohei Ariake,Masamichi Mizuma,Kei Nakagawa,Takanori Morikawa,Toru Furukawa,Michiaki Unno

Nature communications 14:5147 PubMed37620345

2023

RNAPII-dependent ATM signaling at collisions with replication forks.

Applications

Unspecified application

Species

Unspecified reactive species

Elias Einig,Chao Jin,Valentina Andrioletti,Boris Macek,Nikita Popov

Cancers 15: PubMed37627223

2023

Relevance of ATM Status in Driving Sensitivity to DNA Damage Response Inhibitors in Patient-Derived Xenograft Models.

Applications

Unspecified application

Species

Unspecified reactive species

Ankur Karmokar,Rebecca Sargeant,Adina M Hughes,Hana Baakza,Zena Wilson,Sara Talbot,Sarah Bloomfield,Elisabetta Leo,Gemma N Jones,Maria Likhatcheva,Luis Tobalina,Emma Dean,Elaine B Cadogan,Alan Lau

Oncology reports 50: PubMed37477142

2023

Polo‑like kinase 1 selective inhibitor BI2536 (dihydropteridinone) disrupts centrosome homeostasis via ATM‑ERK cascade in adrenocortical carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ruei-Ci Lin,Yu-Ying Chao,Wei-Chih Lien,Huei-Cih Chang,Shih-Wei Tsai,Chia-Yih Wang
View all publications

Abcam product promise

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保証に関する詳細については利用規約をご確認ください。

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Anti-ATM antibody [SP224] - BSA and Azide free

primary-antibodies

atm-antibody-sp224-bsa-and-azide-free-ab213522

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