AB229095

Anti-ATL3 抗体

Anti-ATL3 antibody

JP Deleterious:医薬用外劇物

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(1 Publication)

Rabbit Polyclonal ATL3 antibody. Suitable for WB, IHC-P and reacts with Human, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Atlastin-3.

別名を表示する

Atlastin-3, ATL3

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATL3 antibody (AB229095)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATL3 antibody (AB229095)

Paraffin-embedded rat liver tissue stained for ATL3 protein using ab229095 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATL3 antibody (AB229095)

Paraffin-embedded rat brain tissue stained for ATL3 protein using ab229095 at 1/500 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATL3 antibody (AB229095)

Paraffin-embedded rat cervix tissue stained for ATL3 protein using ab229095 at 1/500 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-ATL3 antibody (AB229095)

7.5 % SDS-PAGE gel.

All lanes:

Western blot - Anti-ATL3 antibody (ab229095) at 1/1000 dilution

All lanes:

NT2/D1 whole cell lysate at 30 µg

Predicted band size: 61 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat, Human

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human Atlastin-3. The exact immunogen used to generate this antibody is proprietary information.

Q6DD88

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The ATL3 protein also known as Atlastin GTPase 3 functions mechanically in cellular processes like membrane fusion. It belongs to the family of dynamin-like GTPases characterized by their ability to hydrolyze GTP to fuel various cellular activities. ATL3 has a molecular mass of about 61 kDa. Expression of ATL3 occurs in various tissues with a significant presence in the brain possibly hinting at its specific roles in neurological functions.

Biological function summary

ATL3 participates in the maintenance of the tubular network of the endoplasmic reticulum (ER). The protein often acts as a dimer and works similarly to other members of the atlastin family. This dimerization and its involvement in membrane fusion aid in creating and maintaining the three-dimensional structure of the ER which is important for various cellular functions and signaling pathways. ATL3 also contributes to the proper spatial arrangement of organelles inside the cells.

Pathways

ATL3 is actively involved in the endoplasmic reticulum morphogenesis pathways. The protein plays an important role in shaping the ER which impacts lipid metabolism and protein synthesis pathways. It closely interacts with other ER-shaping proteins such as ATL1 and ATL2 assisting in retaining the three-dimensional integrity of the ER network that is essential for efficient cellular functioning and response to stress.

Mutations or malfunctions in ATL3 can be associated with hereditary sensory and autonomic neuropathy type I. This relation highlights the significance of ATL3 in neuronal health potentially because of its influence on the ER's structure that affects neuron survival. Additionally there is a connection between ATL3 dysfunction and hereditary spastic paraplegia with ATL1 as another implicated protein indicating a broader impact on neurodegenerative conditions. Understanding ATL3's role not only clarifies its function but also offers insight into potential therapeutic targets for related diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed : 18270207, PubMed : 19665976, PubMed : 27619977).

See full target information Atlastin-3

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

The Journal of biological chemistry 297:101307 PubMed34662580

2021

Neddylation modification of the U3 snoRNA-binding protein RRP9 by Smurf1 promotes tumorigenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Meng-Ge Du,Fan Liu,Yan Chang,Shuai Tong,Wei Liu,Yu-Jiao Chen,Ping Xie

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ATL3 抗体

Anti-ATL3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATL3 antibody (AB229095)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATL3 antibody (AB229095)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATL3 antibody (AB229095)

Western blot - Anti-ATL3 antibody (AB229095)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

代替製品

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise