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AB155286

Anti-Aspartyl Aminopeptidase 抗体 [EPR10300]

Anti-Aspartyl Aminopeptidase antibody [EPR10300]

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(1 Publication)

Rabbit Recombinant Monoclonal Aspartyl Aminopeptidase antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.

別名を表示する

ASPEP, DAP, DNPEP, Aspartyl aminopeptidase

1 Images
Western blot - Anti-Aspartyl Aminopeptidase antibody [EPR10300] (AB155286)
  • WB

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Western blot - Anti-Aspartyl Aminopeptidase antibody [EPR10300] (AB155286)

All lanes:

Western blot - Anti-Aspartyl Aminopeptidase antibody [EPR10300] (ab155286) at 1/1000 dilution

Lane 1:

MCF7 cell lysate at 10 µg

Lane 2:

Human fetal lung lysate at 10 µg

Lane 3:

U-87 MG cell lysate at 10 µg

Lane 4:

HepG2 cell lysate at 10 µg

Lane 5:

Human fetal kidney lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 52 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR10300

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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製品の詳細

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製度
Tissue culture supernatant
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Aspartyl Aminopeptidase also known as DNPEP is a metallopeptidase enzyme that mechanically cleaves N-terminal aspartic acid residues from peptides. This enzyme has a molecular mass of about 52 kDa. Aspartyl Aminopeptidase is expressed in various tissues with high abundance in liver and kidney. Its subcellular location is mainly the cytosol where it is involved in protein processing and turnover.
Biological function summary

Aspastyl aminopeptidase plays a role in peptide metabolism by trimming aspartic acid residues aiding in protein degradation and maturation. It functions independently and is not known to be part of a larger protein complex. Its activity facilitates the maintenance of normal peptide levels which is essential for various cellular processes.

Pathways

Aspartyl aminopeptidase is involved in the renin-angiotensin system an important regulator of blood pressure and fluid balance. Within this pathway it modulates levels of angiotensin peptides. It also interacts with other proteins such as angiotensin-converting enzyme (ACE) and neprilysin highlighting its importance in cardiovascular homeostasis.

Research links aspartyl aminopeptidase to essential hypertension due to its role in the renin-angiotensin system. Abnormal activity of this enzyme might contribute to alterations in angiotensin metabolism therefore impacting blood pressure regulation. Additionally dysregulation may have implications in kidney diseases where interaction with ACE affects renal function and blood pressure control.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism.
See full target information DNPEP
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Biochemistry and biophysics reports 29:101223 PubMed35146136

2022

Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Yasunori Fukumoto,Kemmu Matsuhashi,Yu-Ki Tanaka,Noriyuki Suzuki,Yasumitsu Ogra
View all publications
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代替製品

Primary Antibodies

AB154805

Anti-Aspartyl Aminopeptidase antibody [EPR10301]

RabMAb|Recombinant

Western blot - Anti-Aspartyl Aminopeptidase antibody [EPR10301] (AB154805)

  • 0
  • 0

組合せ製品

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB249105

Anti-UBE2Q2 antibody [EPR10229] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-UBE2Q2 antibody [EPR10229] - BSA and Azide free (AB249105)

  • 0
  • 0
Primary Antibodies

AB134045

Anti-CD63 antibody [EPR5702] - Late Endosome Marker

RabMAb|Recombinant|KO Validated|Lab Essentials|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD63 antibody [EPR5702] - Late Endosome Marker (AB134045)

  • 3
  • 6
Primary Antibodies

AB157465

Anti-DNA polymerase mu antibody [EPR10470(B)]

RabMAb|Recombinant|KO Validated

Western blot - Anti-DNA polymerase mu antibody [EPR10470(B)] (AB157465)

  • 0
  • 0

Abcam product promise

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