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AB228018

Anti-ARSB 抗体

Anti-ARSB antibody

  • JP Deleterious:医薬用外劇物

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(1 Publication)

Rabbit Polyclonal ARSB antibody. Suitable for WB and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ARSB.

別名を表示する

Arylsulfatase B, ASB, N-acetylgalactosamine-4-sulfatase, G4S, ARSB

4 Images
Western blot - Anti-ARSB antibody (AB228018)
  • WB

Supplier Data

Western blot - Anti-ARSB antibody (AB228018)

10% SDS-PAGE

All lanes:

Western blot - Anti-ARSB antibody (ab228018) at 1/1000 dilution

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell extract at 30 µg

Lane 2:

HepG2 (human liver hepatocellular carcinoma cell line) whole cell extract at 30 µg

Predicted band size: 60 kDa

true

Western blot - Anti-ARSB antibody (AB228018)
  • WB

Supplier Data

Western blot - Anti-ARSB antibody (AB228018)

10% SDS-PAGE

All lanes:

Western blot - Anti-ARSB antibody (ab228018) at 1/500 dilution

All lanes:

Rat testis tissue extract at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 36 kDa,60 kDa

true

Western blot - Anti-ARSB antibody (AB228018)
  • WB

Supplier Data

Western blot - Anti-ARSB antibody (AB228018)

10% SDS-PAGE

All lanes:

Western blot - Anti-ARSB antibody (ab228018) at 1/500 dilution

All lanes:

Mouse placenta tissue extract at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 60 kDa

true

Western blot - Anti-ARSB antibody (AB228018)
  • WB

Supplier Data

Western blot - Anti-ARSB antibody (AB228018)

12% SDS-PAGE

All lanes:

Western blot - Anti-ARSB antibody (ab228018) at 1/500 dilution

Lane 1:

Non-transfected HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate.

Lane 2:

HEK-293T transfected with ARSB, whole cell lysate

Predicted band size: 60 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Mouse, Rat, Human

アプリケーション

WB

applications

免疫原

Recombinant Fragment Protein within Human ARSB. The exact immunogen used to generate this antibody is proprietary information.

P15848

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The ARSB protein also known as arylsulfatase B or N-acetylgalactosamine-4-sulfatase is an enzyme weighing approximately 62 kDa. It plays a role in breaking down glycosaminoglycans in the lysosomes. ARSB is highly expressed in tissues such as the liver kidney and skin where its enzymatic activity is important for normal cellular metabolism.
Biological function summary

ARSB functions in the degradation of dermatan sulfate and chondroitin sulfate types of glycosaminoglycans. It works as a monomer and is not part of a larger protein complex. This enzyme targets specific sulfated molecules facilitating their breakdown and recycling within the lysosomes.

Pathways

ARSB is actively involved in the lysosomal degradation pathway one of the key cellular processes for waste removal and recycling of macromolecules. This pathway includes collaboration with other lysosomal enzymes such as iduronate-2-sulfatase to complete the breakdown of complex molecules. ARSB's function in coordination with these enzymes supports cellular maintenance and metabolic balance.

ARSB malfunction is directly linked to the lysosomal storage disorder Mucopolysaccharidosis VI (Maroteaux-Lamy syndrome) characterized by the accumulation of glycosaminoglycans. This deficiency can lead to several symptoms including skeletal abnormalities and organomegaly. ARSB has also shown relevance in some inflammatory disorders where alterations in glycosaminoglycan breakdown impact cellular communication and tissue homeostasis.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (PubMed : 19306108). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (PubMed : 19306108). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity).
See full target information ARSB
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 31:107681 PubMed32460023

2020

Prophase-Specific Perinuclear Actin Coordinates Centrosome Separation and Positioning to Ensure Accurate Chromosome Segregation.

Applications

Unspecified application

Species

Unspecified reactive species

Tom Stiff,Fabio R Echegaray-Iturra,Harry J Pink,Alex Herbert,Constantino Carlos Reyes-Aldasoro,Helfrid Hochegger
View all publications
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代替製品

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組合せ製品

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