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AB74265

Anti-ARRDC4 抗体

Anti-ARRDC4 antibody

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(1 Publication)

Rabbit Polyclonal ARRDC4 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ARRDC4.

別名を表示する

Arrestin domain-containing protein 4, ARRDC4

1 Images
Western blot - Anti-ARRDC4 antibody (AB74265)
  • WB

Unknown

Western blot - Anti-ARRDC4 antibody (AB74265)

All lanes:

Western blot - Anti-ARRDC4 antibody (ab74265) at 1/500 dilution

Lane 1:

extracts from COLO cells at 30 µg

Lane 2:

extracts from COLO cells at 30 µg with immunising peptide

Predicted band size: 45 kDa

Observed band size: 28 kDa,36 kDa,47 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human ARRDC4. The exact immunogen used to generate this antibody is proprietary information.

Q8NCT1

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ARRDC4 also known as arrestin domain-containing protein 4 plays a role in cellular trafficking processes. It is a small protein with a mass of about 41 kDa. This protein gets expressed in various tissues including the lung liver and adipose tissue. ARRDC4 serves as an adaptor protein that helps regulate endocytosis and recycling of different cell surface receptors which is important for maintaining cellular homeostasis.
Biological function summary

ARRDC4 takes part in processes that control receptor recycling and degradation. It does not exist in isolation and works as part of a larger network involving other arrestin proteins. This protein associates with endosomal systems inside cells guiding the internalization and sorting of membrane proteins. By mediating these processes ARRDC4 influences receptor availability on the cell surface affecting cellular response to external signals.

Pathways

ARRDC4 interacts with endocytic pathways to manage receptor internalization and trafficking playing a role in signaling cascades. The protein is found within the ubiquitination pathway where it connects with the NEDD4 E3 ligase family influencing the ubiquitination of membrane proteins. These interactions impact signal transduction pathways important for responses like cell growth and survival.

ARRDC4 connects with metabolic diseases particularly type 2 diabetes as it influences insulin receptor trafficking and function. Altered expression or malfunction of ARRDC4 could affect glucose uptake in cells contributing to insulin resistance. It also relates to cancer through its role in receptor tyrosine kinase regulation potentially altering cancer cell signaling and growth. These functions put ARRDC4 as a point of interest for potential therapeutic interventions in managing such diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (By similarity). Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) (Probable). Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles (By similarity). May play a role in glucose uptake (PubMed : 19605364). Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65 (PubMed : 28594402).
See full target information ARRDC4
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

PloS one 7:e50557 PubMed23236378

2012

Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins.

Applications

ICC/IF

Species

Human

Fortune F Shea,Jennie L Rowell,Yechaowei Li,Tien-Hsien Chang,Carlos E Alvarez
View all publications
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