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AB15123

Anti-Aquaporin 7 抗体

Anti-Aquaporin 7 antibody

4

(1 Review)

|

(4 Publications)

Chicken Polyclonal Aquaporin 7 antibody. Suitable for ELISA, WB, ICC/IF and reacts with Rat samples. Cited in 4 publications.

別名を表示する

Aquaporin-7, AQP-7, Aquaglyceroporin-7, Aqp7

Key facts

宿主種

Chicken

クローン性

Polyclonal

アイソタイプ

IgY

キャリアフリー

No

交差種

Rat

アプリケーション

WB, ICC/IF, ELISA

applications

免疫原

Synthetic Peptide within Rat Aquaporin-7. The exact immunogen used to generate this antibody is proprietary information.

P56403

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

精製度
Whole antiserum
出荷温度
Blue Ice
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 7 (AQP7) sometimes referred to as AQPap is a protein channel that enables the transport of water and small molecules like glycerol across cell membranes. It has a molecular mass of approximately 28 kDa. This protein is widely expressed in adipose tissue kidney and testis where it facilitates critical cellular processes by regulating water and solute flow. The localization of AQP7 in these tissues highlights its key role in the body’s fluid management and metabolic regulation.
Biological function summary

AQP7 plays an important role in maintaining the balance of glycerol and water within cells which is essential for energy homeostasis. It does not function as part of a known complex but works as an individual tetrameric channel. In adipose tissue AQP7 facilitates the release of glycerol consequently affecting lipid metabolism and energy storage. This function contributes significantly to how organisms respond to energy demands and metabolic changes.

Pathways

AQP7 is critical in glycerol transport and lipid metabolism pathways impacting insulin signaling and glucose regulation. AQP7 is closely associated with proteins like adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) which regulate lipid breakdown and mobilization. The interplay between these proteins and AQP7 illustrates its importance in pathways that govern energy balance and metabolic flexibility affecting how cells use stored energy.

AQP7 has associations with metabolic conditions such as obesity and type 2 diabetes. Altered expression or functionality of AQP7 in adipose tissue can influence glycerol release and consequently lipid and glucose metabolism. Dysregulation of AQP7 may also impact metabolic processes by interacting with proteins involved in lipid metabolism like ATGL and HSL. These connections highlight the significance of AQP7 in understanding the molecular basis of metabolic diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea (PubMed : 9252401). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity).
See full target information Aquaporin-7
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Animals : an open access journal from MDPI 13: PubMed37048414

2023

Morphological and Molecular Investigations of Aquaporin-7 (AQP-7) in Male Reproductive Organs.

Applications

Unspecified application

Species

Unspecified reactive species

Thnaian A Al-Thnaian

Journal of oncology 2021:8114327 PubMed34512754

2021

Involvement of Expression in Hepatitis B Virus-Related Hepatocellular Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shaoliang Zhu,Hang Ye,Xiaojie Xu,Weiru Huang,Ziyu Peng,Yingyang Liao,Ningfu Peng

ERJ open research 4: PubMed29577041

2018

Peripheral alveolar nitric oxide concentration reflects alveolar inflammation in autoimmune pulmonary alveolar proteinosis.

Applications

Unspecified application

Species

Unspecified reactive species

Taizou Hirano,Shinya Ohkouchi,Naoki Tode,Makoto Kobayashi,Manabu Ono,Teruyuki Satoh,Yoichiro Mitsuishi,Akira Watanabe,Masao Tabata,Toshiya Irokawa,Hiromasa Ogawa,Hisatoshi Sugiura,Toshiaki Kikuchi,Keiichi Akasaka,Ryushi Tazawa,Yoshikazu Inoue,Koh Nakata,Hajime Kurosawa,Masakazu Ichinose

Reproduction in domestic animals = Zuchthygiene 51:665-79 PubMed27405395

2016

Membrane Stress During Thawing Elicits Redistribution of Aquaporin 7 But Not of Aquaporin 9 in Boar Spermatozoa.

Applications

Unspecified application

Species

Unspecified reactive species

A Vicente-Carrillo,H Ekwall,M Álvarez-Rodríguez,H Rodríguez-Martínez
View all publications
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代替製品

Primary Antibodies

AB305303

Anti-Aquaporin 5 antibody [EPR27474-70]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aquaporin 5 antibody [EPR27474-70] (AB305303)

  • 0
  • 0
Primary Antibodies

AB32826

Anti-Aquaporin 7 antibody

Western blot - Anti-Aquaporin 7 antibody (AB32826)

  • 0
  • 1

組合せ製品

Primary Antibodies

AB125219

Anti-Aquaporin 3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aquaporin 3 antibody (AB125219)

  • 5
  • 6
Primary Antibodies

AB168387

Anti-Aquaporin 1 antibody [EPR11588(B)]

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-Aquaporin 1 antibody [EPR11588(B)] (AB168387)

  • 5
  • 4
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Secondary Antibodies

AB205721

Goat Anti-Chicken IgY H&L (HRP)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Goat Anti-Chicken IgY H&L (HRP) (AB205721)

  • 3
  • 1

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