AB15080

Anti-Aquaporin 1 抗体

Anti-Aquaporin 1 antibody

(17 Reviews)

(68 Publications)

Rabbit Polyclonal Aquaporin 1 antibody. Suitable for ELISA and reacts with Synthetic peptide - Rat samples. Cited in 68 publications. Immunogen corresponding to Synthetic Peptide within Rat Aqp1.

別名を表示する

Chip28, Aqp1, Aquaporin-1, AQP-1, Aquaporin-CHIP

1 Images

ELISA - Anti-Aquaporin 1 antibody (AB15080)

ELISA

Supplier Data

ELISA - Anti-Aquaporin 1 antibody (AB15080)

Antibody titer determination against Aquaporin-1 using pre-immunised serum, Antiserum and Affinity purified Anti-Aquaporin 1 (Cat : ab15080).

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

アプリケーション

ELISA

applications

免疫原

Synthetic Peptide within Rat Aqp1. The exact immunogen used to generate this antibody is proprietary information.

P29975

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Reactivity data

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下記製品もご検討ください

AB168387

Anti-Aquaporin 1 antibody [EPR11588(B)]

4 Reviews

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Whole antiserum

バッファー組成

Constituents: 100% Whole serum

出荷温度

Blue Ice

長期保存温度

-20°C

分注に関する情報

Add glycerol to a final volume of 50% for extra stability and aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 1 also known as Aquaporin-1 AQP-1 or AQP1 is a protein that functions as a water channel facilitating the transport of water across cell membranes. This protein plays an important role in maintaining water homeostasis within cells. Aquaporin 1 has a mass of approximately 28 kDa and is encoded by the AQP1 gene. It is expressed in various tissues and organs including the kidneys lungs and red blood cells indicating its importance in diverse physiological processes.

Biological function summary

Aquaporin 1 is not part of a complex but independently contributes to maintaining osmotic balance and fluid movement across epithelial and endothelial tissues. The protein's selective permeability for water without allowing ions or other solutes highlights its specificity in controlling water transport which is essential for maintaining cellular environment stability.

Pathways

The aquaporin protein is involved in key biological pathways such as the osmoregulatory pathway and the fluid secretion pathway. It maintains efficient water transport in processes like urine concentration in the kidneys and fluid regulation in the pulmonary system. Aquaporins in general are related to similar transport proteins like sodium channels which together play an important role in maintaining osmotic balance across various tissues.

Aquaporin 1's dysfunction has been associated with conditions such as nephrogenic diabetes insipidus and pulmonary edema. These are linked to its role in water reabsorption in the kidneys and fluid balance in the lungs. The disorder's connection ties Aquaporin-1 with other regulatory proteins such as vasopressin receptors which work in conjunction to control renal water reabsorption and response to fluid imbalance.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo.

See full target information Aqp1

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文献 (68)

Recent publications for all applications. Explore the full list and refine your search

Stem cells international 2023:8344259 PubMed37223543

2023

Human Platelet-Rich Plasma Regulates Canine Mesenchymal Stem Cell Migration through Aquaporins.

Applications

Unspecified application

Species

Unspecified reactive species

Alessia Parascandolo,Michele Francesco Di Tolla,Domenico Liguoro,Manuela Lecce,Saverio Misso,Fabiana Micieli,Maria Rosaria Ambrosio,Serena Cabaro,Francesco Beguinot,Alessandra Pelagalli,Vittoria D'Esposito,Pietro Formisano

Cancer discovery 12:2308-2329 PubMed35758895

2022

A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Phillip M Rappold,Lynda Vuong,Josef Leibold,Nicholas H Chakiryan,Michael Curry,Fengshen Kuo,Erich Sabio,Hui Jiang,Briana G Nixon,Ming Liu,Anders E Berglund,Andrew W Silagy,Eduardo A Mascareno,Mahdi Golkaram,Mahtab Marker,Albert Reising,Alexander Savchenko,John Millholland,Ying-Bei Chen,Paul Russo,Jonathan Coleman,Ed Reznik,Brandon J Manley,Irina Ostrovnaya,Vladimir Makarov,Renzo G DiNatale,Kyle A Blum,Xiaoxiao Ma,Diego Chowell,Ming O Li,David B Solit,Scott W Lowe,Timothy A Chan,Robert J Motzer,Martin H Voss,A Ari Hakimi

PloS one 17:e0268541 PubMed35709078

2022

Aquaporin 4 is not present in normal porcine and human lamina cribrosa.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth C Kimball,Sarah Quillen,Mary E Pease,Casey Keuthan,Aru Nagalingam,Donald J Zack,Thomas V Johnson,Harry A Quigley

Acta physiologica (Oxford, England) 235:e13828 PubMed35543087

2022

Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP receptor upregulation in mouse and human kidney.

Applications

Unspecified application

Species

Unspecified reactive species

Signe S Tofteng,Line Nilsson,Amalie K Mogensen,Rikke Nørregaard,Rolf Nüsing,Mikhail Diatchikhine,Lars Lund,Claus Bistrup,Boye L Jensen,Kirsten Madsen

Clinical science (London, England : 1979) 135:2393-2408 PubMed34622923

2021

Chronic activation of AMP-activated protein kinase leads to early-onset polycystic kidney phenotype.

Applications

Unspecified application

Species

Unspecified reactive species

Laura Wilson,Alice E Pollard,Lucy Penfold,Phillip J Muckett,Chad Whilding,Mohammad Bohlooly-Y,Patricia Wilson,David Carling

Cell metabolism 33:1793-1807.e9 PubMed34358431

2021

Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4 endothelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Zheng Fan,Guillermo Turiel,Raphaela Ardicoglu,Moheb Ghobrial,Evi Masschelein,Tea Kocijan,Jing Zhang,Ge Tan,Gillian Fitzgerald,Tatiane Gorski,Abdiel Alvarado-Diaz,Paola Gilardoni,Christopher M Adams,Bart Ghesquière,Katrien De Bock

JCI insight 6: PubMed34156031

2021

Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Wang,Shi-Ting Wu,Xi Yang,Yude Qian,Jaesung P Choi,Rui Gao,Siliang Song,Yixuan Wang,Tao Zhuang,Justin Jl Wong,Yuzhen Zhang,Zhiming Han,Hua A Lu,Stephen I Alexander,Renjing Liu,Yin Xia,Xiangjian Zheng

Nature communications 12:2190 PubMed33850129

2021

Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney.

Applications

Unspecified application

Species

Unspecified reactive species

Yoshiharu Muto,Parker C Wilson,Nicolas Ledru,Haojia Wu,Henrik Dimke,Sushrut S Waikar,Benjamin D Humphreys

JCI insight 6: PubMed33591958

2021

Macrophage-derived PDGF-B induces muscularization in murine and human pulmonary hypertension.

Applications

Unspecified application

Species

Unspecified reactive species

Aglaia Ntokou,Jui M Dave,Amy C Kauffman,Maor Sauler,Changwan Ryu,John Hwa,Erica L Herzog,Inderjit Singh,W Mark Saltzman,Daniel M Greif

PloS one 16:e0244123 PubMed33529207

2021

The role of aquaporin-4 in optic nerve head astrocytes in experimental glaucoma.

Applications

Unspecified application

Species

Unspecified reactive species

Elizabeth Kimball,Julie Schaub,Sarah Quillen,Casey Keuthan,Mary Ellen Pease,Arina Korneva,Harry Quigley

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

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Anti-Aquaporin 1 抗体

Anti-Aquaporin 1 antibody

ELISA - Anti-Aquaporin 1 antibody (AB15080)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

アプリケーション

免疫原

Reactivity data

下記製品もご検討ください

Anti-Aquaporin 1 antibody [EPR11588(B)]

こちらの製品も推奨する理由

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (68)

Abcam product promise

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