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AB193612

Anti-Apoptin 抗体

Anti-Apoptin antibody

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(3 Publications)

Rabbit Polyclonal Apoptin antibody. Suitable for WB, ELISA and reacts with Chicken anemia virus samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Chicken anemia virus Cuxhaven-1/Germany VP3.

別名を表示する

Apoptin, VP3

1 Images
Western blot - Anti-Apoptin antibody (AB193612)
  • WB

Supplier Data

Western blot - Anti-Apoptin antibody (AB193612)

All lanes:

Western blot - Anti-Apoptin antibody (ab193612) at 2 µg/mL

All lanes:

Chicken anemia virus apoptin at 0.4 µg

Secondary

All lanes:

Polyclonal goat anti-rabbit at 1/10000 dilution

Predicted band size: 13 kDa,41 kDa

Observed band size: 40 kDa,41 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Chicken anemia virus

アプリケーション

WB, ELISA

applications

免疫原

Recombinant Full Length Protein corresponding to Chicken anemia virus Cuxhaven-1/Germany VP3.

Q99152

特異性

Reacts with Chicken anemia virus.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chicken anemia virus": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
精製に関する特記事項
> 95%
バッファー組成
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Apoptin also known as Chicken Anemia Virus Protein is a small protein with a mass of approximately 13.8 kDa. It expresses in various cell types including both normal and transformed cells. However Apoptin shows a unique ability to localize within the nucleus primarily in transformed cells. This nuclear localization is a critical feature as it is closely linked with its pro-apoptotic activity whereas in normal cells it remains in the cytoplasm rendering it inactive in these cells.
Biological function summary

Without the addition of other interacting proteins Apoptin initiates programmed cell death specifically in cancerous or transformed cells. It functions as a monomer and does not require a complex to exert its apoptotic effects. Its specificity offers a promising cancer therapeutic strategy as it discriminates between cancerous and non-cancerous cells leading to selective cytotoxicity.

Pathways

Multiple studies indicate that Apoptin triggers apoptosis through pathways distinct from the typical p53-dependent mechanisms. It activates processes related to the intrinsic apoptotic pathway bypassing p53 which makes it valuable in targeting p53-deficient tumors. Additionally Apoptin interacts with proteins related to the apoptotic pathway including Bcl-2 homology 3 (BH3) enhancing mitochondrial membrane permeability.

Apoptin has shown potential relevance to cancer making it a target of interest in cancer research and therapy. Its ability to induce apoptosis selectively in cancer cells without harming normal cells relates it to several cancer types. Furthermore its mechanism connects to p53-related proteins offering insights into therapeutic developments for p53-deficient cancers. Apart from cancer researchers are exploring its potential role in viral infections given its origin from Chicken Anemia Virus which may lead to broader therapeutic applications.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

May act as transcriptional regulator. Induces apoptosis in infected cells. Element of infectious replication cycle.
See full target information VP3
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Investigational new drugs 39:949-960 PubMed33534026

2021

Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Shang,Yi-Long Zhu,Yi-Quan Li,Gao-Jie Song,Chen-Chen Ge,Jing Lu,Zhi-Ru Xiu,Wen-Jie Li,Shan-Zhi Li,Jia-Nan Cong,Zi-Rui Liu,Xiao Li,Li-Li Sun,Ning-Yi Jin

Technology in cancer research & treatment 18:1533033819875166 PubMed31769345

2019

Targeted Inhibitory Effect of Nasopharyngeal Carcinoma Cells by Hre.Grp78 Chimeric Promoter Regulating Fusion Gene .

Applications

Unspecified application

Species

Unspecified reactive species

Jin-Yun Li,Wen-Xiao Huang,Jie Chen,Su-Ping Zhao,Yao-Yun Tang

Oncology letters 13:579-586 PubMed28356932

2017

Human serum albumin-mediated apoptin delivery suppresses breast cancer cell growth and .

Applications

Unspecified application

Species

Unspecified reactive species

Fang Wu,Yizhi Liu,Jian Li,Lei Hou,Fuxi Lei,Shangke Huang,Lu Feng,Xinhan Zhao
View all publications
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