AB191695

Anti-APOBEC3B 抗体 - N-terminal

Name: Anti-APOBEC3B 抗体 - N-terminal (ab191695) | Abcam
Brand: Abcam Limited
SKU: AB191695
Price: 77000 JPY
Availability: InStock

Anti-APOBEC3B antibody - N-terminal

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(12 Publications)

Rabbit Polyclonal APOBEC3B antibody. N-terminal. Suitable for WB, IHC-P and reacts with Human samples. Cited in 12 publications. Immunogen corresponding to Synthetic Peptide within Human APOBEC3B.

別名を表示する

DNA dC->dU-editing enzyme APOBEC-3B, A3B, Phorbolin-1-related protein, Phorbolin-2/3, APOBEC3B

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC3B antibody - N-terminal (AB191695)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC3B antibody - N-terminal (AB191695)

Immunohistochemical analysis of paraffin-embedded Human small intestine tissue, labeling APOBEC3B using ab191695 at 5 μg/mL.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC3B antibody - N-terminal (AB191695)

Immunohistochemical analysis of human small intestine tissue, labeling APOBEC3B using ab191695 at 20 μg/mL.

Supplier Data

Western blot - Anti-APOBEC3B antibody - N-terminal (AB191695)

All lanes:

Western blot - Anti-APOBEC3B antibody - N-terminal (ab191695) at 1 µg/mL

All lanes:

HepG2 cell lysate

Predicted band size: 46 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P, WB

applications

免疫原

Synthetic Peptide within Human APOBEC3B. The exact immunogen used to generate this antibody is proprietary information.

Q9UH17

特異性

ab191695 will detect all three isoforms of APOBEC3B. ab191695 may cross-react with APOBEC3D.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

APOBEC3B also known as Apolipoprotein B mRNA editing enzyme catalytic subunit 3B is a protein that plays a role in DNA cytosine deamination. It selectively deaminates cytosine bases in DNA to uracil resulting in mutations. The protein has a molecular mass of approximately 46 kDa. APOBEC3B expression occurs primarily in the liver and testes but it can also be detected in other tissues.

Biological function summary

APOBEC3B functions as part of the innate immune defense by restricting viral replication through inducing hypermutation in viral genomes. It does not form a stable complex but can act in conjunction with other APOBEC3 family members. APOBEC3B activity is critical in the context of host-virus interactions especially in the defense against retroviruses and other viruses.

Pathways

Scientists classify APOBEC3B within the viral restriction and DNA damage response pathways. In these pathways the protein works alongside other DNA repair proteins such as AID (Activation-Induced cytidine Deaminase). APOBEC3B participates in editing events that provide insights into virus-host co-evolution and resilience against viral infections.

Researchers have linked APOBEC3B to cancer development due to its ability to induce genetic mutations. Its mutagenic activity connects it with a variety of cancers including breast cancer and head and neck cancer. Through these diseases the protein shows functional connections to other DNA mutators and repair proteins that it affects or interacts with during tumorigenesis.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons.

See full target information APOBEC3B

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文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Oncology research 32:1021-1030 PubMed38827321

2024

New insights into ATR inhibition in muscle invasive bladder cancer: The role of apolipoprotein B mRNA editing catalytic subunit 3B.

Applications

Unspecified application

Species

Unspecified reactive species

Hyunho Kim,Uiju Cho,Sook Hee Hong,Hyung Soon Park,In-Ho Kim,Ho Jung An,Byoung Yong Shim,Jin Hyoung Kang

Translational cancer research 12:2673-2681 PubMed37969401

2023

Prognostic value of APOBEC3A in patients with cervical squamous cell carcinoma in a major urban center in China: a retrospective study.

Applications

Unspecified application

Species

Unspecified reactive species

Haiwei He,Shenglian Lu,Nan Lu,Nian Huang,Mingjuan Xu

Cancer cell 41:1427-1449.e12 PubMed37478850

2023

Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoling Li,Yunguan Wang,Su Deng,Guanghui Zhu,Choushi Wang,Nickolas A Johnson,Zeda Zhang,Carla Rodriguez Tirado,Yaru Xu,Lauren A Metang,Julisa Gonzalez,Atreyi Mukherji,Jianfeng Ye,Yuqiu Yang,Wei Peng,Yitao Tang,Mia Hofstad,Zhiqun Xie,Heewon Yoon,Liping Chen,Xihui Liu,Sujun Chen,Hong Zhu,Douglas Strand,Han Liang,Ganesh Raj,Housheng Hansen He,Joshua T Mendell,Bo Li,Tao Wang,Ping Mu

International journal of clinical and experimental pathology 16:48-56 PubMed37033395

2023

APOBEC3B expression has prognostic significance in cervical cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Si-Qi Zhang,Jun Zhang,Yang Yu,Miao-Mei Yu,Jiang Wei,Yan-Hong Tang

Diagnostics (Basel, Switzerland) 13: PubMed36766673

2023

APOBEC3B Is Co-Expressed with PKCα/NF-κB in Oral and Oropharyngeal Squamous Cell Carcinomas.

Applications

Unspecified application

Species

Unspecified reactive species

Galinos Fanourakis,Efthymios Kyrodimos,Vasileios Papanikolaou,Aristeidis Chrysovergis,Georgia Kafiri,Nikolaos Papanikolaou,Mihalis Verykokakis,Konstantinos Tosios,Heleni Vastardis

Disease markers 2022:2147494 PubMed35903294

2022

Prognostic Value of HPV E6 and APOBEC3B in Upper Urinary Tract Urothelial Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Le He,Bo Yang,Dan Jian,Hao Luo,Dong Wang,Nan Dai

Frontiers in immunology 13:888250 PubMed35592333

2022

Aberrantly Activated APOBEC3B Is Associated With Mutant p53-Driven Refractory/Relapsed Diffuse Large B-Cell Lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xuzhao Zhang,Zhaoxing Wu,Yuanyuan Hao,Teng Yu,Xian Li,Yun Liang,Jinfan Li,Liansheng Huang,Yang Xu,Xiuzhen Li,Xiaohua Xu,Weiqin Wang,Genbo Xu,Xiaohong Zhang,Qinghua Lv,Yongming Fang,Rongzhen Xu,Wenbin Qian

Oncotarget 11:3354-3370 PubMed32934779

2020

GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma and APOBEC3B is directly transcriptionally regulated by GATA3.

Applications

Unspecified application

Species

Unspecified reactive species

Sudheer Kumar Gara,Monica Varun Tyagi,Dhaval Thakkur Patel,Kelli Gaskins,Justin Lack,Yi Liu,Electron Kebebew

Oncology letters 19:3205-3214 PubMed32256817

2020

APOBEC3B expression and its prognostic potential in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Mao,Meng Lv,Yuzi Zhang,Gang Nie,Jian Cui,Yongmei Wang,Yuanyuan Wang,Weihong Cao,Xiaoyi Liu,Xingang Wang,Haibo Wang

Applied immunohistochemistry & molecular morphology : AIMM 27:599-605 PubMed30095460

2018

APOBEC3B High Expression in Gastroenteropancreatic Neuroendocrine Neoplasms and Association With Lymph Metastasis.

Applications

Unspecified application

Species

Unspecified reactive species

Changyin Feng,Qiaoling Zheng,Yinghong Yang,Meifang Xu,Yuane Lian,Jianping Huang,Yiting Jiang

View all publications

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Abcam product promise

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Anti-APOBEC3B 抗体 - N-terminal

Anti-APOBEC3B antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC3B antibody - N-terminal (AB191695)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APOBEC3B antibody - N-terminal (AB191695)

Western blot - Anti-APOBEC3B antibody - N-terminal (AB191695)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (12)

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise