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リコンビナントRabMAb

Anti-APLP1 抗体 [EPR25737-6] - BSA and Azide free (Capture) (ab290676)

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Sandwich ELISA - Anti-APLP1 antibody [EPR25737-6] - BSA and Azide free (Capture) (ab290676)
  • Anti-APLP1 antibody [EPR25737-6] - BSA and Azide free (Capture) (ab290676)

Key features and details

  • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
  • Rabbit monoclonal [EPR25737-6] to APLP1 - BSA and Azide free (Capture)
  • Suitable for: Sandwich ELISA
  • Reacts with: Mouse, Rat, Human

製品の概要

  • 製品名

    Anti-APLP1 antibody [EPR25737-6] - BSA and Azide free (Capture)
    APLP1 一次抗体 製品一覧

  • 製品の詳細

    Rabbit monoclonal [EPR25737-6] to APLP1 - BSA and Azide free (Capture)

  • 由来種

    Rabbit

  • アプリケーション

    適用あり: Sandwich ELISAmore details

  • 種交差性

    交差種: Mouse, Rat, Human

  • 免疫原

    Recombinant fragment. This information is proprietary to Abcam and/or its suppliers.

  • 特記事項

    ab290676 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human, Mouse and Rat APLP1. The recommended pair for sandwich ELISA is:
         Capture: ab290676 , Human, Mouse, Rat APLP1 Capture Antibody (unconjugated)
         Detector: ab290677 , Human, Mouse, Rat APLP1 Detector Antibody (unconjugated)
    The reference range value is 31 -2000 pg/mL.

    This product is a recombinant monoclonal antibody, which offers several advantages including:

    • - High batch-to-batch consistency and reproducibility
    • - Improved sensitivity and specificity
    • - Long-term security of supply
    • - Animal-free production
    For more information see here.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

製品の特性

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab290676の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
Sandwich ELISA
Use at an assay dependent concentration. Can be paired for Sandwich ELISA with PE / R-Phycoerythrin Conjugation Kit - Lightning-Link® (ab102918) and Streptavidin Conjugation Kit - Lightning-Link® (ab102921) and Biotinylation Kit / Biotin Conjugation Kit (Fast and Type A) - Lightning-Link® (ab201795) and Rabbit monoclonal [EPR25737-4] to APLP1 - BSA and Azide free (Detector) (ab290677).
特記事項
Sandwich ELISA
Use at an assay dependent concentration. Can be paired for Sandwich ELISA with PE / R-Phycoerythrin Conjugation Kit - Lightning-Link® (ab102918) and Streptavidin Conjugation Kit - Lightning-Link® (ab102921) and Biotinylation Kit / Biotin Conjugation Kit (Fast and Type A) - Lightning-Link® (ab201795) and Rabbit monoclonal [EPR25737-4] to APLP1 - BSA and Azide free (Detector) (ab290677).

ターゲット情報

  • 機能

    May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.
    The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis.

  • 組織特異性

    Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD).

  • 配列類似性

    Belongs to the APP family.

  • ドメイン

    The NPXY sequence motif found in many tyrosine-phosphorylated proteins is required for the specific binding of the PID domain. However, additional amino acids either N- or C-terminal to the NPXY motif are often required for complete interaction. The NPXY site is also involved in clathrin-mediated endocytosis.

  • 翻訳後修飾

    Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-620 by caspase-3.
    N- and O-glycosylated. O-glycosylation with core 1 or possibly core 8 glycans. Glycosylation on Ser-227 is the preferred site to Thr-228.

  • 細胞内局在

    Cell membrane and Cytoplasm. C-terminally processed in the Golgi complex.
  • Information by UniProt

  • 参照データベース

    • 別名

      • AMYLOID BETA A4 PRECURSOR-LIKE PROTEIN 1 antibody
      • AMYLOID PRECURSOR-LIKE PROTEIN antibody
      • Amyloid-like protein 1 precursor antibody
      • APLP 1 antibody
      • APLP antibody
      • APLP-1 antibody
      • Aplp1 antibody
      • APLP1_HUMAN antibody
      • C30 antibody
      see all

    画像

    • Sandwich ELISA - Anti-APLP1 antibody [EPR25737-6] - BSA and Azide free (Capture) (ab290676)
      Sandwich ELISA - Anti-APLP1 antibody [EPR25737-6] - BSA and Azide free (Capture) (ab290676)
      Sandwich ELISA of ab290703 with the capture antibody dilution at 2 µg/mL and detector antibody dilution at 0.5 µg/mL.
    • Anti-APLP1 antibody [EPR25737-6] - BSA and Azide free (Capture) (ab290676)
      Anti-APLP1 antibody [EPR25737-6] - BSA and Azide free (Capture) (ab290676)

    プロトコール

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    参考文献 (0)

    ab290676 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab290676 は論文での使用が確認できていません。

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