APC/Cy7® Anti-CD11b 抗体 [M1/70] (ab79096)
![Flow Cytometry - APC/Cy7® Anti-CD11b antibody [M1/70] (ab79096)](https://www.abcam.co.jp/ps/products/79/ab79096/Images/ab79096-277190-anti-cd11b-antibody-m1-70-allophycocyanin-cy7-flow-cytometry.jpg "Flow Cytometry - APC/Cy7® Anti-CD11b antibody [M1/70] (ab79096)")
Key features and details
- APC/Cy7® Rat monoclonal [M1/70] to CD11b
- Suitable for: Flow Cyt
- Reacts with: Mouse, Rat
- Conjugation: APC/Cy7®. Ex: 650nm, Em: 774nm
- Isotype: IgG2b
Related conjugates and formulations
製品の概要
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製品名
APC/Cy7® Anti-CD11b antibody [M1/70]
CD11b 一次抗体 製品一覧 -
製品の詳細
APC/Cy7® Rat monoclonal [M1/70] to CD11b -
由来種
Rat -
標識
APC/Cy7®. Ex: 650nm, Em: 774nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse, Rat -
免疫原
Tissue, cells or virus corresponding to Mouse CD11b. C57BL/10 mouse splenic T cells and concanavaline A-activated C57BL/10 splenocytes.
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ポジティブ･コントロール
- Flow Cyt: Mouse splenocytes.
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特記事項
This product or portions thereof is manufactured under license from Carnegie Mellon University under U.S. Patent Number 5, 268, 486 and related patents. Cy® and CyDye® are trademarks of Cytiva.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Do Not Freeze. Store In the Dark. -
バッファー
pH: 7.20
Preservative: 0.09% Sodium azide
Constituents: 0.1% Gelatin, 0.12% Monobasic dihydrogen sodium phosphate, 0.88% Sodium chloride -
Concentration information loading... -
精製度
Affinity purified -
ポリ/モノ
モノクローナル -
クローン名
M1/70 -
アイソタイプ
IgG2b -
軽鎖の種類
kappa -
研究分野
関連製品
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Alternative Versions
- Alexa Fluor® 488 Anti-CD11b antibody [M1/70] (ab197701)
- Alexa Fluor® 647 Anti-CD11b antibody [M1/70] (ab197702)
- PerCP/Cy5.5® Anti-CD11b antibody [M1/70] (ab210299)
- PE/Cy7® Anti-CD11b antibody [M1/70] (ab218786)
- Anti-CD11b antibody [M1/70] - BSA and Azide free (ab237965)
- violetFluor™ 450 Anti-CD11b antibody [M1/70] (ab242266)
- FITC Anti-CD11b antibody [M1/70] (ab24874)
- PE Anti-CD11b antibody [M1/70] (ab25175)
- redFluor™ 710 Anti-CD11b antibody [M1/70] (ab253091)
- APC Anti-CD11b antibody [M1/70] (ab25482)
- PE/Cy5® Anti-CD11b antibody [M1/70] (ab25533)
- Anti-CD11b antibody [M1/70] (ab8878)
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab79096の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. |
ターゲット情報
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機能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. -
組織特異性
Predominantly expressed in monocytes and granulocytes. -
関連疾患
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 16409 Mouse
- Entrez Gene: 25021 Rat
- SwissProt: P05555 Mouse
- Unigene: 262106 Mouse
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別名
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
see all
画像
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Flow Cytometry - APC/Cy7® Anti-CD11b antibody [M1/70] (ab79096)
C57Bl/6 bone marrow cells stained with 0.125µg ab79096 (solid line) or 0.125µg APC-Cy7-conjugated rat IgG2b isotype control (dashed line).
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab79096 は 1 報の論文で使用されています。
- Das LM et al. Hyper-inflammation and skin destruction mediated by rosiglitazone activation of macrophages in IL-6 deficiency. J Invest Dermatol 135:389-399 (2015). PubMed: 25184961