Anti-APC2 抗体 (ab113370)
Key features and details
- Rabbit polyclonal to APC2
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-APC2 antibody
APC2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to APC2 -
由来種
Rabbit -
アプリケーション
適用あり: WB, IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse
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免疫原
Synthetic peptide corresponding to Human APC2 (internal sequence) conjugated to keyhole limpet haemocyanin.
Database link: O95996 -
ポジティブ･コントロール
- Human Brain Cortex and Small Intestine tissues; HeLa cell lysate.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.4
Preservative: 0.02% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab113370の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 244 kDa.
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| IHC-P | (1) |
Use a concentration of 5 µg/ml.
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| 特記事項 |
|---|
|
WB
Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 244 kDa. |
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IHC-P
Use a concentration of 5 µg/ml. |
ターゲット情報
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機能
Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling. -
組織特異性
Widely expressed (at protein level). Specifically expressed in the CNS. -
配列類似性
Belongs to the adenomatous polyposis coli (APC) family.
Contains 6 ARM repeats. -
発生段階
Expressed in fetal brain. -
細胞内局在
Cytoplasm, cytoskeleton. Golgi apparatus. Cytoplasm. Cytoplasm, perinuclear region. Associated with actin filaments (PubMed:11691822). Associated with microtubule network (PubMed:10644998, PubMed:11691822). - Information by UniProt
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参照データベース
- Entrez Gene: 10297 Human
- SwissProt: O95996 Human
- SwissProt: Q9Z1K7 Mouse
- Unigene: 446376 Human
- Unigene: 57247 Mouse
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別名
- Adenomatous polyposis coli protein 2 antibody
- Adenomatous polyposis coli protein-like antibody
- APC-like antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APC2 antibody (ab113370)ab113370, at 5 µg/ml, staining APC2 in Formalin-fixed, Paraffin-embedded Human Brain cortex tissue by Immunohistochemistry.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APC2 antibody (ab113370)ab113370, at 5 µg/ml, staining APC2 in Formalin-fixed, Paraffin-embedded Human Small intestine tissue by Immunohistochemistry. -
Western blot - Anti-APC2 antibody (ab113370)Lane 1 : Anti-APC2 antibody (ab113370) at 1 µg/ml
Lane 2 : Anti-APC2 antibody (ab113370) at 2 µg/ml
All lanes : HeLa cell lysate
Predicted band size: 244 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab113370 は 3 報の論文で使用されています。
- Rashid F et al. Induction of miR-3648 Upon ER Stress and Its Regulatory Role in Cell Proliferation. Int J Mol Sci 18:N/A (2017). WB ; Human . PubMed: 28661420
- Najafi H et al. Alternative splicing of the OCC-1 gene generates three splice variants and a novel exonic microRNA, which regulate the Wnt signaling pathway. RNA 23:70-85 (2017). PubMed: 27986894
- Hebert AM et al. Merlin/ERM proteins establish cortical asymmetry and centrosome position. Genes Dev 26:2709-23 (2012). WB ; Human . PubMed: 23249734