Anti-Apc11 抗体 (ab154546)
Key features and details
- Rabbit polyclonal to Apc11
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Apc11 antibody -
製品の詳細
Rabbit polyclonal to Apc11 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat, Cow, Xenopus laevis, Zebrafish, Xenopus tropicalis -
免疫原
Synthetic peptide, corresponding to a region within amino acids 26-84 of Human Apc11 (Uniprot ID: Q9NYG5).
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ポジティブ・コントロール
- 293T, H1299, HeLaS3, HepG2, MOLT4, Raji whole cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine) -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab154546の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 9 kDa.
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特記事項 |
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WB
1/500 - 1/3000. Predicted molecular weight: 9 kDa. |
ターゲット情報
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機能
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. -
組織特異性
Expressed at high levels in skeletal muscle and heart; in moderate levels in brain, kidney, and liver; and at low levels in colon, thymus, spleen, small intestine, placenta, lung and peripheral blood leukocyte. -
パスウェイ
Protein modification; protein ubiquitination. -
配列類似性
Belongs to the RING-box family.
Contains 1 RING-type zinc finger. -
ドメイン
The RING-type zinc finger domain coordinates an additional third zinc ion. -
翻訳後修飾
Auto-ubiquitinated. -
細胞内局在
Cytoplasm. Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 616275 Cow
- Entrez Gene: 51529 Human
- Entrez Gene: 66156 Mouse
- Entrez Gene: 498030 Rat
- Entrez Gene: 496247 Xenopus laevis
- Entrez Gene: 496610 Xenopus tropicalis
- Entrez Gene: 768140 Zebrafish
- Omim: 614534 Human
see all -
別名
- ANAPC 11 antibody
- ANAPC11 antibody
- Anaphase promoting complex subunit 11 (yeast APC11 homolog) antibody
see all
画像
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (2)
ab154546 は 2 報の論文で使用されています。
- Lee SH et al. SIRT1 ubiquitination is regulated by opposing activities of APC/C-Cdh1 and AROS during stress-induced premature senescence. Exp Mol Med 55:1232-1246 (2023). PubMed: 37258580
- Zhou CJ et al. CENP-F-dependent DRP1 function regulates APC/C activity during oocyte meiosis I. Nat Commun 13:7732 (2022). PubMed: 36513638