APC Anti-Transferrin Receptor 抗体 [MEM-75], prediluted (ab64672)
Key features and details
- APC Mouse monoclonal [MEM-75] to Transferrin Receptor, prediluted
- Suitable for: Flow Cyt
- Reacts with: Human
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG1
Related conjugates and formulations
製品の概要
-
製品名
APC Anti-Transferrin Receptor antibody [MEM-75], prediluted
Transferrin Receptor 一次抗体 製品一覧 -
製品の詳細
APC Mouse monoclonal [MEM-75] to Transferrin Receptor, prediluted -
由来種
Mouse -
標識
APC. Ex: 645nm, Em: 660nm -
特異性
ab64672 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. ab64672 does not block binding of transferrin to the receptor. -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human Transferrin Receptor. NALM-6 human pre-B cell line
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.4
Preservative: 0.097% Sodium azide
Constituents: PBS, 0.2% BSA -
Concentration information loading... -
精製度
Size exclusion -
特記事項（精製）
The purified antibody (>95% by SDS-PAGE) is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. -
ポリ/モノ
モノクローナル -
クローン名
MEM-75 -
アイソタイプ
IgG1 -
研究分野
関連製品
-
Alternative Versions
- PE Anti-Transferrin Receptor antibody [MEM-75] (ab18242)
- APC/Cy7® Anti-Transferrin Receptor antibody [MEM-75] (ab233254)
- FITC Anti-Transferrin Receptor antibody [MEM-75] (ab239251)
- PerCP/Cy5.5® Anti-Transferrin Receptor antibody [MEM-75] (ab239340)
- Alexa Fluor® 700 Anti-CD43 antibody [MEM-59] (ab270666)
- Alexa Fluor® 700 Anti-Transferrin Receptor antibody [MEM-75] (ab270667)
- Biotin Anti-Transferrin Receptor antibody [MEM-75] (ab28116)
- Anti-Transferrin Receptor antibody [MEM-75] (ab9179)
-
Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab64672の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
| 特記事項 |
|---|
追加情報
Flow Cyt: Use 10µl for 106 cells or 100µl of whole blood.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
-
機能
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
(Microbial infection) Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. -
関連疾患
Immunodeficiency 46 -
配列類似性
Belongs to the peptidase M28 family. M28B subfamily.
Contains 1 PA (protease associated) domain. -
翻訳後修飾
N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).
Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation. -
細胞内局在
Secreted and Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. - Information by UniProt
-
参照データベース
- Entrez Gene: 7037 Human
- Omim: 190010 Human
- SwissProt: P02786 Human
- Unigene: 529618 Human
-
別名
- CD 71 antibody
- CD71 antibody
- CD71 antigen antibody
see all
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (0)
ab64672 は論文での使用が確認できていません。