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AB278589

APC Anti-MEK3 (phospho S189) + MKK6 (phospho S207) 抗体 [MKK3S189MKK6S207-D3]

APC Anti-MEK3 (phospho S189) + MKK6 (phospho S207) antibody [MKK3S189MKK6S207-D3]

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Rabbit Recombinant Monoclonal MEK3 phospho S189 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Synthetic Peptide within Human MAP2K3 phospho S189.

別名を表示する

MEK3, MKK3, PRKMK3, SKK2, MAP2K3, Dual specificity mitogen-activated protein kinase kinase 3, MAP kinase kinase 3, MAPKK 3, MAPK/ERK kinase 3, Stress-activated protein kinase kinase 2, MEK 3, SAPK kinase 2, SAPKK-2, SAPKK2

1 Images
Flow Cytometry - APC Anti-MEK3 (phospho S189) + MKK6 (phospho S207) antibody [MKK3S189MKK6S207-D3] (AB278589)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC Anti-MEK3 (phospho S189) + MKK6 (phospho S207) antibody [MKK3S189MKK6S207-D3] (AB278589)

Flow cytometric analysis of HEK293T cells K252a treated cells as negative control (blue) or stained and treated with K252a (red) or treated with UV+TPA (green) using ab278589.

関連する標識済み抗体及び組成の異なる製品 (3)

  • Unconjugated

    Anti-MEK 3 (phospho S189) + MKK6 (phospho S207) antibody [MKK3S189MKK6S207-D3]

  • 578 PE

    PE Anti-MEK3 (phospho S189) + MKK6 (phospho S207) antibody [MKK3S189MKK6S207-D3]

  • 519 FITC

    FITC Anti-MEK3 (phospho S189) + MKK6 (phospho S207) antibody [MKK3S189MKK6S207-D3]

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

MKK3S189MKK6S207-D3

アイソタイプ

IgG

軽鎖のタイプ

kappa

標識

APC

励起波長/蛍光波長

Ex: 650nm, Em: 660nm

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

Synthetic Peptide within Human MAP2K3 phospho S189. Database link P46734

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }
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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A/G
バッファー組成
Preservative: 0.09% Sodium azide Constituents: PBS, 0.2% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

MEK3 also known as MAP2K3 and MKK6 known as MAP2K6 are protein kinases involved in the MAP kinase signaling pathway. MEK3 has a molecular weight of approximately 38 kDa and MEK6 has a similar molecular weight. Researchers have identified these kinases in various human tissues with significant expression in muscles heart and brain tissues. Both MEK3 and MKK6 activate specific downstream MAP kinases via phosphorylation facilitating their role in cellular stress responses.
Biological function summary

MEK3 and MKK6 mediate responses to stress and inflammatory cytokines marking their importance in signal transduction. They activate p38 MAP kinase through phosphorylation a part of a complex necessary for cellular responses. This activity influences gene expression related to cellular growth differentiation and apoptosis. MEK3 and MKK6 show functional overlap and redundancy ensuring robust cellular responses to external stimuli.

Pathways

MEK3 and MKK6 are integral in the MAP kinase signaling pathway and the p38 MAPK pathway. These pathways play critical roles in cell differentiation apoptosis and response to extracellular stress signals. MEK3 and MEK6 phosphorylate and activate the p38 MAPK protein which regulates stress-induced gene expression. This relationship emphasizes the interplay between kinases and how MEK3 and MEK6 fit within broader signaling networks.

MEK3 and MKK6 are associated with inflammatory diseases and cancer. Dysregulation of the p38 MAPK pathway involving MEK3 and MKK6 contributes to these conditions due to improper stress response signaling. Notably MEK6's interaction with the p38 protein highlights its potential role in exacerbating inflammation and tumorigenesis. Understanding the mechanisms involving MEK3 and MKK6 assists in the development of targeted therapies for these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14.
See full target information MAP2K3 phospho S189

追加のターゲット

MAP2K6 phospho S207
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組合せ製品

Assay Kits

AB279860

Phospho-MEK3 (S189) ELISA Kit

Sandwich ELISA - Phospho-MEK3 (S189) ELISA Kit (AB279860)

  • 0
  • 0
Primary Antibodies

AB278724

PE Anti-ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187) antibody [ERK12T202Y204-A11]

Recombinant

Flow Cytometry - PE Anti-ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187) antibody [ERK12T202Y204-A11] (AB278724)

  • 0
  • 0
Primary Antibodies

AB278759

APC Anti-MEK1 + MEK2 (phospho S218 + S222) antibody [MEK12S217S221-H2]

Recombinant

Flow Cytometry - APC Anti-MEK1 + MEK2 (phospho S218 + S222) antibody [MEK12S217S221-H2] (AB278759)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB278695

FITC Anti-Src (phospho Y416) antibody [SrcY416-C4]

Recombinant

Flow Cytometry - FITC Anti-Src (phospho Y416) antibody [SrcY416-C4] (AB278695)

  • 0
  • 0

Abcam product promise

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