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AB200593

APC/Cy7® Anti-CD2 抗体 [TS18], prediluted

APC/Cy7® Anti-CD2 antibody [TS18]

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(1 Publication)

Anti-CD2 antibody [TS18] conjugated to APC/Cy7® - suitable for flow cytometry, and reacts with human samples. Clone [TS18] is a mouse monoclonal antibody.

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別名を表示する

CD2, SRBC, T-cell surface antigen CD2, Erythrocyte receptor, LFA-2, LFA-3 receptor, Rosette receptor, T-cell surface antigen T11/Leu-5

3 Images
Flow Cytometry - APC/Cy7® Anti-CD2 antibody [TS18] (AB200593)
  • Flow Cyt

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Flow Cytometry - APC/Cy7® Anti-CD2 antibody [TS18] (AB200593)

Flow Cytometry analysis of Human peripheral blood cells labeling CD2 with Anti-CD2 antibody [TS18], prediluted (Allophycocyanin/Cy7 ®) (ab200593).

Flow Cytometry - APC/Cy7® Anti-CD2 antibody [TS18] (AB200593)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC/Cy7® Anti-CD2 antibody [TS18] (AB200593)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab200593 (concentration in sample 0.04 µg/ml).

Flow Cytometry - APC/Cy7® Anti-CD2 antibody [TS18] (AB200593)
  • Flow Cyt

Supplier Data

Flow Cytometry - APC/Cy7® Anti-CD2 antibody [TS18] (AB200593)

Flow cytometry surface staining pattern of human peripheral whole blood stained using ab200593 (concentration in sample 0.04 µg/ml).

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

TS18

アイソタイプ

IgG1

標識

APC/Cy7®

励起波長/蛍光波長

Ex: 650nm, Em: 785nm

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing CD2 protein. The exact immunogen used to generate this antibody is proprietary information.

P06729

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代替製品

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組合せ製品

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Primary Antibodies

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Primary Antibodies

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>4 μl / 100 μl of whole blood</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Size-exclusion chromatography
精製に関する特記事項
ab200593 is conjugated with tandem dye APC-Cy under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
バッファー組成
pH: 7.4 Preservative: 0.098% Sodium azide Constituents: PBS, 0.2% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Do Not Freeze|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD2 also known as T11 or LFA-2 acts as a cell surface glycoprotein expressed mainly on T-cells natural killer cells and thymocytes. This protein has a molecular mass of approximately 50-55 kDa. CD2 plays a critical role in facilitating cell-cell adhesion and signal transduction. It serves as a receptor for the CD58 ligand on antigen-presenting cells supporting the interaction between T-cells and these cells. By enhancing adhesion CD2 contributes to the formation of the immunological synapse necessary for effective immune response.
Biological function summary

The functioning of CD2 helps in the modulation of immune responses and T-cell activation. CD2 participates in signal transduction leading to cytokine production and proliferation. It is associated with the immunological synapse complex working closely with other surface molecules like Lck and CD3 to promote T-cell responses. This collaboration is vital for the development and function of immune cells driving adaptive immunity.

Pathways

CD2 engages in pathways integral to T-cell activation and signal transduction. A well-known pathway involving CD2 is the TCR (T-cell Receptor) signaling pathway where it partners with CD3 to initiate T-cell activation. Additionally CD2 influences the LAT (Linker for Activation of T-cells) pathway contributing to downstream signaling cascades that involve various signaling proteins such as Lck and ZAP-70 ensuring proper T-cell function.

CD2 shows connections to autoimmune diseases and cancers. For instance its involvement in abnormal T-cell activation links CD2 to autoimmune conditions like rheumatoid arthritis. Also various leukemias demonstrate altered CD2 expression suggesting a role in cancer pathogenesis. Through these disease states CD2's interaction with the CD58 protein becomes critical as this interaction affects the activity of T-cells in the disease milieu influencing disease progression and treatment outcomes.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
See full target information CD2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:8008 PubMed39271671

2024

MASTER-NAADP: a membrane permeable precursor of the Ca mobilizing second messenger NAADP.

Applications

Unspecified application

Species

Unspecified reactive species

Sarah Krukenberg,Franziska Möckl,Mariella Weiß,Patrick Dekiert,Melanie Hofmann,Fynn Gerlach,Kai J Winterberg,Dejan Kovacevic,Imrankhan Khansahib,Berit Troost,Macarena Hinrichs,Viviana Granato,Mikolaj Nawrocki,Tobis Hub,Volodymyr Tsvilovskyy,Rebekka Medert,Lena-Marie Woelk,Fritz Förster,Huan Li,René Werner,Marcus Altfeld,Samuel Huber,Oliver Biggs Clarke,Marc Freichel,Björn-Philipp Diercks,Chris Meier,Andreas H Guse
View all publications
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Abcam product promise

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