AB18280

APC Anti-CD4 抗体 [MEM-241]

Name: APC Anti-CD4 抗体 [MEM-241] (ab18280) | Abcam
Brand: Abcam Limited
SKU: AB18280
Price: 16000 JPY
Availability: InStock

APC Anti-CD4 antibody [MEM-241]

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(2 Publications)

Mouse Monoclonal CD4 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD4.

別名を表示する

CD4, T-cell surface glycoprotein CD4, T-cell surface antigen T4/Leu-3

2 Images

Flow Cytometry - APC Anti-CD4 antibody [MEM-241] (AB18280)

Flow Cyt

Unknown

Flow Cytometry - APC Anti-CD4 antibody [MEM-241] (AB18280)

Surface staining of human peripheral blood cells with anti-human CD4 (MEM-241) APC.

Flow Cyt

Unknown

Flow Cytometry - APC Anti-CD4 antibody [MEM-241] (AB18280)

Overlay histogram showing peripheral blood lymphocytes stained with ab18280 (red line). The cells were incubated with the antibody (ab18280, 1/20 dilution) for 30 min at 4°C. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2μg/1x10⁶ cells) with secondary antibody DyLight® 649 goat anti-mouse IgG (H&L) (ab96882) at 1/200 dilution for 30 min at 4°C. Acquisition of >5,000 events was performed gating on peripheral blood lymphocytes.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

MEM-241

アイソタイプ

IgG1

軽鎖のタイプ

kappa

標識

APC

励起波長/蛍光波長

Ex: 650nm, Em: 660nm

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Recombinant Fragment Protein within Human CD4. The exact immunogen used to generate this antibody is proprietary information.

P01730

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/20", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/apc-mouse-fab2-igg1-kappa-monoclonal-15h6-isotype-control-ab37391'>ab37391</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.4 Preservative: 0.097% Sodium azide Constituents: BSA, PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule : peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.. (Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1) (PubMed : 12089508, PubMed : 16331979, PubMed : 2214026, PubMed : 9641677). Down-regulated by HIV-1 Vpu (PubMed : 17346169). Acts as a receptor for Human Herpes virus 7/HHV-7 (PubMed : 7909607).

See full target information CD4

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Tissue engineering and regenerative medicine 21:609-624 PubMed38568409

2024

Effects of Mesenchymal Stem Cells-Derived Extracellular Vesicles on Inhibition of Hepatic Fibrosis by Delivering miR-200a.

Applications

Unspecified application

Species

Unspecified reactive species

Ai-Lei Xu,Long Han,Jun Yan,Dan Liu,Wei Wang

Cancer cell international 21:58 PubMed33468159

2021

IRF4 overexpression promotes the transdifferentiation of tregs into macrophage-like cells to inhibit the development of colon cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiwei Wang,Song Li,Honglang Li,Xiaoshuang Zhou,Huabin Wen,Bin Lai

View all publications

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代替製品

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組合せ製品

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Primary Antibodies

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Secondary Antibodies

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