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AB25457

APC Anti-CD23 抗体 [2G8]

APC Anti-CD23 antibody [2G8]

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(1 Publication)

Rat Monoclonal CD23 antibody - conjugated to APC. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 1 publication.

別名を表示する

CD23, CD23A, CLEC4J, FCE2, IGEBF, FCER2, Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor

1 Images
Flow Cytometry - APC Anti-CD23 antibody [2G8] (AB25457)
  • Flow Cyt

Unknown

Flow Cytometry - APC Anti-CD23 antibody [2G8] (AB25457)

Flow cytometry analysis of BALB/c mouse splenocytes labeling CD23 with ab25457 at 0.1 μg/106cells and CD3 epsilon with Rat Anti-Mouse CD3 epsilon-FITC.

Key facts

宿主種

Rat

クローン性

Monoclonal

クローン番号

2G8

アイソタイプ

IgG2a

軽鎖のタイプ

kappa

標識

APC

励起波長/蛍光波長

Ex: 650nm, Em: 660nm

キャリアフリー

No

交差種

Mouse

アプリケーション

Flow Cyt

applications

特異性

ab25457 recognises CD23 low affinity IgE Fc receptor.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "0.1 µg for 10^6 Cells", "FlowCyt-species-notes": "<p>ab129719 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification
バッファー組成
pH: 7.3 Preservative: 0.09% Sodium azide Constituents: PBS, 16% Sucrose
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD23 also known as Fc epsilon receptor II (FcεRII) or BU38 is a type II integral membrane protein with a molecular mass of approximately 45 kDa. It is expressed mainly on B cells but also appears on various other cell types such as macrophages eosinophils and Langerhans cells. CD23 expression occurs in both soluble and membrane-bound forms. The protein consists of a lectin-like extracellular domain a short transmembrane domain and a cytoplasmic tail.
Biological function summary

CD23 facilitates several immune functions including the regulation of immunoglobulin E (IgE) production and its receptor-mediated endocytosis. It has a role in cell adhesion growth and differentiation. CD23 exists independently localizing primarily to the surface of CD23-positive cells. Furthermore this protein influences the release and activity of various cytokines impacting both innate and adaptive immunity.

Pathways

CD23 plays central roles in IgE-mediated immune responses and allergic reactions. It is importantly involved in the synthesis and regulation of IgE connecting it to the IgE signaling pathway and immune system pathways. CD23 interacts with IgE and its receptors which include the high-affinity receptor FcεRI forming an interface between the antigen and immune effector functions. Additionally CD23 participates in pathways that involve immune response modulation and inflammation prevention.

CD23 is most notably associated with allergic diseases such as asthma and allergic rhinitis due to its role in IgE regulation. It is also linked to chronic lymphocytic leukemia (CLL) in which CD23 serves as a marker for disease progression. In CLL interactions involving CD23 and related proteins such as BCMA and BAFF have been studied to better understand the disorder and its treatment. Anti-CD23 antibodies have been used as both diagnostic tools and therapeutic agents to target CD23-positive cells in these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed : 2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed : 7544003).
See full target information FCER2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of immunology (Baltimore, Md. : 1950) 180:4994-5003 PubMed18354225

2008

Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity.

Applications

Flow Cyt

Species

Mouse

Keith Hamel,Paul Doodes,Yanxia Cao,Yumei Wang,Jeffrey Martinson,Robert Dunn,Marilyn R Kehry,Balint Farkas,Alison Finnegan
View all publications
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代替製品

Primary Antibodies

AB16702

Anti-CD23 antibody [SP23]

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry - Anti-CD23 antibody [SP23] (AB16702)

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Primary Antibodies

AB135386

Anti-CD23 antibody [SP163]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CD23 antibody [SP163] (AB135386)

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  • 0
Primary Antibodies

AB245732

Anti-CD23 antibody [SP163] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CD23 antibody [SP163] - BSA and Azide free (AB245732)

  • 0
  • 0
Primary Antibodies

AB92495

Anti-CD23 antibody [EPR3617]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD23 antibody [EPR3617] (AB92495)

  • 0
  • 0
Primary Antibodies

AB242380

Anti-CD23 antibody [SP23] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry - Anti-CD23 antibody [SP23] - BSA and Azide free (AB242380)

  • 4
  • 1

組合せ製品

Assay Kits

AB272468

Human CD23 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human CD23 ELISA Kit (AB272468)

  • 0
  • 0
Primary Antibodies

AB305209

Alexa Fluor® 647 Anti-CD45 antibody [EPR20033]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD45 antibody [EPR20033] (AB305209)

  • 0
  • 0
Primary Antibodies

AB134080

Anti-CD30 antibody [EPR4102]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD30 antibody [EPR4102] (AB134080)

  • 0
  • 0
Primary Antibodies

AB281930

Alexa Fluor® 594 Anti-CD21 antibody [EP3093]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 594 Anti-CD21 antibody [EP3093] (AB281930)

  • 0
  • 0
Primary Antibodies

AB275738

Alexa Fluor® 488 Anti-CD11c antibody [EP1347Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 488 Anti-CD11c antibody [EP1347Y] (AB275738)

  • 4
  • 1

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