APC Anti-CD19 抗体 [6D5] (ab25484)
![Flow Cytometry - APC Anti-CD19 antibody [6D5] (ab25484)](https://www.abcam.co.jp/ps/products/25/ab25484/Images/ab25484-272403-anti-cd19-antibody-6d5-allophycocyanin-flow-cytometry.jpg "Flow Cytometry - APC Anti-CD19 antibody [6D5] (ab25484)")
Key features and details
- APC Rat monoclonal [6D5] to CD19
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: APC. Ex: 645nm, Em: 660nm
- Isotype: IgG2a
Related conjugates and formulations
製品の概要
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製品名
APC Anti-CD19 antibody [6D5]
CD19 一次抗体 製品一覧 -
製品の詳細
APC Rat monoclonal [6D5] to CD19 -
由来種
Rat -
標識
APC. Ex: 645nm, Em: 660nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse CD19. Mouse CD19-expressing K562 human erythroleukemia cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Store In the Dark. -
バッファー
pH: 7.3
Preservative: 0.09% Sodium azide
Constituents: PBS, 16% Sucrose
Stabilising agent. -
Concentration information loading... -
精製度
Affinity purified -
ポリ/モノ
モノクローナル -
クローン名
6D5 -
アイソタイプ
IgG2a -
軽鎖の種類
kappa -
研究分野
関連製品
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Alternative Versions
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab25484の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt | (2) |
| 特記事項 |
|---|
IP: Use at an assay dependent dilution.
In vivo and in vitro functional studies: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
ターゲット情報
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機能
Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. -
関連疾患
Defects in CD19 are the cause of immunodeficiency common variable type 3 (CVID3) [MIM:613493]; also called antibody deficiency due to CD19 defect. CVID3 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. -
配列類似性
Contains 2 Ig-like C2-type (immunoglobulin-like) domains. -
翻訳後修飾
Phosphorylated on serine and threonine upon DNA damage, probably by ATM or ATR. Phosphorylated on tyrosine following B-cell activation. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 12478 Mouse
- SwissProt: P25918 Mouse
- Unigene: 4360 Mouse
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別名
- Antibody deficiency due to defect in CD19 antibody
- Antibody deficiency due to defect in CD19, included antibody
- AW495831 antibody
see all
画像
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Flow Cytometry - APC Anti-CD19 antibody [6D5] (ab25484)
Flow cytometric analysis of BALB/c mouse splenocytes labelling CD19 with ab25484 at 0.03 μg/106 cells and labelling CD3 epsilon with a Rat Anti-Mouse CD3-FITC antibody (ab24948).
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab25484 は 4 報の論文で使用されています。
- Harding CL et al. Plasmodium Impairs Antibacterial Innate Immunity to Systemic Infections in Part Through Hemozoin-Bound Bioactive Molecules. Front Cell Infect Microbiol 10:328 (2020). PubMed: 32714882
- Krop I et al. Self-renewal of B-1 lymphocytes is dependent on CD19. Eur J Immunol 26:238-42 (1996). PubMed: 8566073
- Krop I et al. The signaling activity of murine CD19 is regulated during cell development. J Immunol 157:48-56 (1996). PubMed: 8683154
- Fearon DT The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes. Curr Opin Immunol 5:341-8 (1993). PubMed: 7688513