Anti-Anthrax EF/Adenylyl cyclase 抗体 (ab21267)
Key features and details
- Rabbit polyclonal to Anthrax EF/Adenylyl cyclase
- Suitable for: ELISA
- Reacts with: Bacillus anthracis
- Isotype: IgG
製品の概要
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製品名
Anti-Anthrax EF/Adenylyl cyclase antibody -
製品の詳細
Rabbit polyclonal to Anthrax EF/Adenylyl cyclase -
由来種
Rabbit -
アプリケーション
適用あり: ELISAmore details -
種交差性
交差種: Bacillus anthracis -
免疫原
Synthetic peptide corresponding to Anthrax EF/Adenylyl cyclase (C terminal).
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. -
バッファー
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab21267の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use a concentration of 1 µg/ml. Note: at this concentration ab21267 will detect 10 ng of free peptide.
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特記事項 |
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ELISA
Use a concentration of 1 µg/ml. Note: at this concentration ab21267 will detect 10 ng of free peptide. |
ターゲット情報
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関連性
Anthrax infection is initiated by inhalation, ingestion or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF) and edema factor (EF). PA binds to two related proteins on the cell surface; these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin like protease. The bound fragment binds both LF and EF; the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. EF is a calmodulin and Ca++ dependent adenylate cyclase responsible for the edema seen in the disease. It is thought to benefit the B. anthracis bacteria by inhibiting cells of the host immune system. -
別名
- Adenylyl cyclase antibody
- Bacillus anthracis EF antibody
- Cya antibody
see all
プロトコール
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab21267 は 1 報の論文で使用されています。
- He L et al. Deficiency of FAM3D (Family With Sequence Similarity 3, Member D), A Novel Chemokine, Attenuates Neutrophil Recruitment and Ameliorates Abdominal Aortic Aneurysm Development. Arterioscler Thromb Vasc Biol 38:1616-1631 (2018). PubMed: 29853563