Anti-ANKRD1 抗体 (ab64963)
Key features and details
- Rabbit polyclonal to ANKRD1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-ANKRD1 antibody
ANKRD1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to ANKRD1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Mouse
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免疫原
Synthetic peptide (Human) from an internal region
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab64963の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa).
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| 特記事項 |
|---|
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WB
1/500 - 1/1000. Detects a band of approximately 36 kDa (predicted molecular weight: 36 kDa). |
ターゲット情報
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機能
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. -
組織特異性
Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells. -
関連疾患
Defects in ANKRD1 may be a cause of total anomalous pulmonary venous return (TAPVR) [MIM:106700]. TAPVR is a rare congenital heart disease (CHD) in which the pulmonary veins fail to connect to the left atrium during cardiac development, draining instead into either the right atrium or one of its venous tributaries. This disease accounts for 1.5% of all CHDs and has a prevalence of approximately 1 out of 15'000 live births. -
配列類似性
Contains 5 ANK repeats. -
細胞内局在
Nucleus. - Information by UniProt
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参照データベース
- Entrez Gene: 27063 Human
- Entrez Gene: 107765 Mouse
- Omim: 609599 Human
- SwissProt: Q15327 Human
- SwissProt: Q9CR42 Mouse
- Unigene: 448589 Human
- Unigene: 10279 Mouse
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別名
- ALRP antibody
- ANKR1_HUMAN antibody
- ANKRD 1 antibody
see all
画像
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Western blot - Anti-ANKRD1 antibody (ab64963)All lanes : Anti-ANKRD1 antibody (ab64963) at 1/500 dilution
Lane 1 : COLO205 cell extract
Lane 2 : COLO205 cell extract with immunising peptide at 5 µg
Lysates/proteins at 5 µg per lane.
Predicted band size: 36 kDa
Observed band size: 36 kDa
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (3)
ab64963 は 3 報の論文で使用されています。
- Benkner A et al. Riociguat attenuates the changes in left ventricular proteome and microRNA profile after experimental aortic stenosis in mice. Br J Pharmacol 179:4575-4592 (2022). PubMed: 35751875
- Kempton A et al. Altered regulation of cardiac ankyrin repeat protein in heart failure. Heliyon 4:e00514 (2018). PubMed: 29560432
- Band M et al. The muscle ankyrin repeat proteins are hypoxia-sensitive: in vivo mRNA expression in the hypoxia-tolerant blind subterranean mole rat, Spalax ehrenbergi. J Mol Evol 70:1-12 (2010). WB ; Rat, Other species . PubMed: 19967343