JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB108294

Anti-Angiotensinogen 抗体 [EPR2930(2)]

Anti-Angiotensinogen antibody [EPR2930(2)]

Be the first to review this product! Submit a review

|

(2 Publications)

Rabbit Recombinant Monoclonal Angiotensinogen antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

別名を表示する

SERPINA8, AGT, Angiotensinogen, Serpin A8

1 Images
Western blot - Anti-Angiotensinogen antibody [EPR2930(2)] (AB108294)
  • WB

Unknown

Western blot - Anti-Angiotensinogen antibody [EPR2930(2)] (AB108294)

All lanes:

Western blot - Anti-Angiotensinogen antibody [EPR2930(2)] (ab108294) at 1/10000 dilution

Lane 1:

Human fetal kidney lysate at 10 µg

Lane 2:

Human fetal artery lysate at 10 µg

Lane 3:

Human fetal heart lysate at 10 µg

Lane 4:

HepG2 cell lysate at 10 µg

Lane 5:

Human plasma lysate at 10 µg

Predicted band size: 53 kDa

false

関連する標識済み抗体及び組成の異なる製品 (1)

  • Carrier free

    Anti-Angiotensinogen antibody [EPR2930(2)] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR2930(2)

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
style
left-column

下記製品にもご興味をお持ちいただけるかもしれません:

AB287170

Human AGT ELISA Kit

0

0 Reviews

製品ページを見る
こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

お客様の実験に適するかご確認いただくため、必ず製品データシートをご確認いただくことをお勧めいたします。ご不明点等ございましたら、テクニカルサポートチームまでお問い合わせください。

style
left-column

製品の詳細

style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Stable for 12 months at -20°C
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Angiotensinogen also known as AGT is a precursor to angiotensin peptides and plays a mechanical role in the renin-angiotensin system. It is a glycoprotein with a mass of approximately 60 kDa and is mainly produced in the liver. This protein circulates in the bloodstream where it waits for renin to cleave it. Angiotensinogen's presence is significant in various tissues but primarily it functions within the plasma after hepatic secretion.
Biological function summary

Angiotensinogen is critical in the regulation of blood pressure and fluid balance. It serves as the substrate for renin an enzyme that initiates a cascade leading to the production of angiotensin I which further converts into active forms like angiotensin II. Angiotensinogen does not operate as part of a larger protein complex but interacts closely with enzymes and other substrates to mediate its effects on the cardiovascular system.

Pathways

Angiotensinogen is an essential component of the renin-angiotensin-aldosterone system (RAAS) which helps regulate blood pressure and electrolyte balance. The pathway involves the conversion of angiotensinogen to angiotensin I by renin followed by the conversion to angiotensin II by angiotensin-converting enzyme (ACE). This system also has connections with proteins such as aldosterone which is involved in sodium and water retention influencing cardiovascular health.

Angiotensinogen links to hypertension and cardiovascular diseases. The protein's interaction with renin and ACE results in the formation of angiotensin II a potent vasoconstrictor that increases blood pressure. Elevated levels of angiotensinogen are often observed in individuals with high 117/85 blood pressure indicating a risk for chronic conditions. Managing angiotensinogen levels through RAAS modulation is a therapeutic strategy for controlling these disorders.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.. Angiotensin-2. Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone (PubMed : 10619573, PubMed : 17138938). Acts by binding to angiotensin receptors AGTR1 and AGTR2 (PubMed : 1567413). Also binds the DEAR/FBXW7-AS1 receptor (By similarity).. Angiotensin-3. Stimulates aldosterone release.. Angiotensin 1-7. Is a ligand for the G-protein coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (By similarity).
See full target information AGT
style
left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Pflugers Archiv : European journal of physiology 471:949-959 PubMed30980137

2019

Intermittent normobaric hypoxia facilitates high altitude acclimatization by curtailing hypoxia-induced inflammation and dyslipidemia.

Applications

Unspecified application

Species

Unspecified reactive species

Anamika Gangwar, Pooja,Manish Sharma,Krishan Singh,Anita Patyal,Gopinath Bhaumik,Kalpana Bhargava,Niroj Kumar Sethy

The Journal of biological chemistry 290:5749-58 PubMed25568318

2015

Dexamethasone promotes hypertension by allele-specific regulation of the human angiotensinogen gene.

Applications

Unspecified application

Species

Unspecified reactive species

Varunkumar G Pandey,Sudhir Jain,Anita Rana,Nitin Puri,Sri Krishna C Arudra,Brahmaraju Mopidevi,Meenakshi Kaw,Alberto Nasjletti,Ashok Kumar
View all publications
style
left-column
style
left-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
style
left-column
style
right-column

関連製品

Select an associated product type
Alternative Product
Primary Antibodies

AB97381

Anti-Angiotensinogen antibody

primary-antibodies

angiotensinogen-antibody-ab97381

0

(0 reviews)

Alternative Product
Primary Antibodies

AB216411

Anti-Angiotensinogen antibody

primary-antibodies

angiotensinogen-antibody-ab216411

0

(0 reviews)

Alternative Product
Primary Antibodies

AB236317

Anti-Angiotensinogen antibody

primary-antibodies

angiotensinogen-antibody-ab236317

0

(0 reviews)

Alternative Product
Primary Antibodies

AB213705

Anti-Angiotensinogen antibody [EPR20599]

primary-antibodies

angiotensinogen-antibody-epr20599-ab213705

0

(0 reviews)

Alternative Product
Primary Antibodies

AB108334

Anti-Angiotensinogen antibody [EPR2931]

primary-antibodies

angiotensinogen-antibody-epr2931-ab108334

3

(4 reviews)

Alternative Product
Primary Antibodies

AB81270

Anti-Angiotensinogen antibody [EPR3136Y]

primary-antibodies

angiotensinogen-antibody-epr3136y-ab81270

0

(0 reviews)

Alternative Product
Primary Antibodies

AB240389

Anti-Angiotensinogen antibody [EPR20599] - BSA and Azide free

primary-antibodies

angiotensinogen-antibody-epr20599-bsa-and-azide-free-ab240389

0

(0 reviews)

Alternative Product
Primary Antibodies

AB238173

Anti-Angiotensinogen antibody [EPR22199-203] - BSA and Azide free

primary-antibodies

angiotensinogen-antibody-epr22199-203-bsa-and-azide-free-ab238173

0

(0 reviews)

Alternative Product
Primary Antibodies

AB229005

Anti-Angiotensinogen antibody [EPR22199-203]

primary-antibodies

angiotensinogen-antibody-epr22199-203-ab229005

5

(2 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com