AB124505

Anti-Angiotensin II Type 1 Receptor 抗体

Name: Anti-Angiotensin II Type 1 Receptor 抗体 (ab124505) | Abcam
Brand: Abcam Limited
SKU: AB124505
Price: 73000 JPY
Availability: InStock
Rating: 2 (2 reviews)

Anti-Angiotensin II Type 1 Receptor antibody

(2 Reviews)

(41 Publications)

Rabbit Polyclonal Angiotensin II Type 1 Receptor antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse samples. Cited in 41 publications. Immunogen corresponding to Synthetic Peptide within Human AGTR1.

別名を表示する

AGTR1A, AGTR1B, AT2R1, AT2R1B, AGTR1, Type-1 angiotensin II receptor, AT1AR, AT1BR, Angiotensin II type-1 receptor, AT1 receptor

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

Immunohistochemical analysis of mouse kidney tissue section labelling Angiotensin II Type 1 Receptor with ab124505, at 2.5 μg/ml.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

ab124505, at 2.5 µg/ml, staining Angiotensin II Type 1 Receptor in paraffin-embedded Mouse kidney tissue by Immunohistochemistry.

Immunocytochemistry/ Immunofluorescence - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

Immunofluorescence of AGTR1 in mouse kidney cells using ab124505 at 20 ug/ml.

Unknown

Western blot - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

Lane 1:

Western blot - Anti-Angiotensin II Type 1 Receptor antibody (ab124505) at 1 µg/mL

Lane 2:

Western blot - Anti-Angiotensin II Type 1 Receptor antibody (ab124505) at 2 µg/mL

All lanes:

Mouse kidney tissue lysate at 15 µg

Predicted band size: 41 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Mouse

アプリケーション

IHC-P, ICC/IF, WB

applications

免疫原

Synthetic Peptide within Human AGTR1. The exact immunogen used to generate this antibody is proprietary information.

P30556

特異性

ab124505 is specific for Angiotensin II Type 1 Receptor (AGTR1) and will not cross-react with AGTR2.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "2.5 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Angiotensin II Type 1 Receptor also known as AGTR1 AT1 receptor or Angiotensin Receptor 1 is a G protein-coupled receptor with a mass of approximately 45 kDa. This receptor binds to the angiotensin II peptide playing a central role in regulating blood pressure. It is broadly expressed in tissues such as vascular smooth muscle cells cardiac myocytes kidneys and brain. The AT1 receptor mediates vasoconstriction aldosterone secretion and cellular growth through its interaction with angiotensin II impacting cardiovascular functions.

Biological function summary

The Angiotensin II Type 1 Receptor contributes significantly to the regulation of cardiovascular homeostasis. It forms part of a complex signaling system involving G proteins phospholipase C and other downstream effectors. This receptor elicits responses important for maintaining vascular tone and fluid balance. By activating intracellular signaling cascade it plays an essential role in sodium reabsorption and systemic blood pressure maintenance. The receptor's expression and activity represent an important component in cardiovascular function.

Pathways

The AT1 receptor participates actively in the renin-angiotensin system (RAS) and is a significant player in the regulation of blood pressure. It interacts with angiotensin converting enzyme (ACE) and angiotensin II within this pathway. Additionally the receptor is linked to the mitogen-activated protein kinase (MAPK) pathway which further influences cell proliferation and vascular remodeling. These interactions highlight the receptor's involvement in vascular smooth muscle cell function and the broader implications for cardiovascular health.

The Angiotensin II Type 1 Receptor is closely associated with conditions such as hypertension and heart failure. Dysfunction or overactivity of this receptor contributes to elevated blood pressure and compromised cardiac function. The AT1 receptor's connection to ACE highlights its therapeutic relevance as many antihypertensive treatments target this interaction. By modulating the receptor's activity these treatments aim to alleviate symptoms and reduce the risk of cardiovascular events.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed : 15611106, PubMed : 1567413, PubMed : 25913193, PubMed : 26420482, PubMed : 30639100, PubMed : 32079768, PubMed : 8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed : 15611106).. (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis.

See full target information AGTR1

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文献 (41)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular life sciences : CMLS 82:201 PubMed40369324

2025

Taurolidine inhibits influenza virus infection and prevents influenza-induced cytokine storm, vasoconstriction and lung damage.

Applications

Unspecified application

Species

Unspecified reactive species

Chaoxiang Lv,Jin Guo,Rongbo Luo,Yuanguo Li,Bingshuo Qian,Xiaopan Zou,Tiecheng Wang,Beilei Shen,Weiyang Sun,Yuwei Gao

BMC nephrology 25:470 PubMed39716128

2024

Fasting recovers age-related hypertension in the rats: reset of renal renin-angiotensin system components and klotho.

Applications

Unspecified application

Species

Unspecified reactive species

Firuzeh Badreh,Siyavash Joukar,Mohammad Badavi,Mohammad Rashno

Kidney & blood pressure research 49:1075-1090 PubMed39571568

2024

Renal and Vascular Functional Decline in Aged Low Birth Weight Murine Adults.

Applications

Unspecified application

Species

Unspecified reactive species

May M Rabadi,Marella R Verde,Mia Camilliere,Nicholas Vecchio,Sharath Kandhi,Miroslav Sekulic,Michael S Wolin,Brian B Ratliff

Kidney research and clinical practice 44:461-480 PubMed39384346

2024

Exploring new horizons: angiotensin II, angiotensin II type 1 receptor, and renal outer medullary potassium channel interaction in distal convoluted tubule.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Zhao,Tiantian Han,Linzhen Jia,Libo Wen,Renjun Gao,Xue Li

Virus research 340:199300 PubMed38092254

2023

Angiotensin converting enzyme 2 does not facilitate porcine epidemic diarrhea virus entry into porcine intestinal epithelial cells and inhibits it-induced inflammatory injury by promoting STAT1 phosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhiqiang Li,Xueqing Chen,Chang Ma,Xinyu Du,Yuanshu Zhang

Acta pharmacologica Sinica 45:137-149 PubMed37640899

2023

Sirtuin 6 protects against podocyte injury by blocking the renin-angiotensin system by inhibiting the Wnt1/β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Hua Miao,Yan-Ni Wang,Wei Su,Liang Zou,Shou-Gang Zhuang,Xiao-Yong Yu,Fei Liu,Ying-Yong Zhao

Aging 15:7673-7688 PubMed37552124

2023

Emodin attenuates diabetic kidney disease by inhibiting ferroptosis via upregulating Nrf2 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Ji,Pengyu Tao,Qian Wang,Mengmeng Cui,Mingfeng Cao,Yuzhen Xu

Pharmaceutical biology 61:858-867 PubMed37211627

2023

Gastrodin attenuates angiotensin II-induced vascular contraction and MLCK/p-MLC pathway activation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhi Guo,Xuan Yang,Meizhu Wu,Aling Shen,Jiapeng Li,Xiuli Zhang,Ying Cheng,Qiurong Xie,Jun Peng

Journal of the renin-angiotensin-aldosterone system : JRAAS 2022:9162427 PubMed36660420

2022

IgA Nephropathy with Macroproteinuria and a GFR of 20-30 ml/min/1.73 m May Still Benefit from RAS Inhibition.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Wang,Shimin Jiang,Guming Zou,Li Zhuo,Wenge Li

Frontiers in endocrinology 13:1004289 PubMed36479219

2022

Factors associated with the progression of mesangial lesions in IgA nephropathy: A comparative analysis of renal re-biopsies.

Applications

Unspecified application

Species

Unspecified reactive species

Yetong Li,Shimin Jiang,Hongmei Gao,Yue Yang,Xiaorong Liu,Wenge Li

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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Anti-Angiotensin II Type 1 Receptor 抗体

Anti-Angiotensin II Type 1 Receptor antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

Immunocytochemistry/ Immunofluorescence - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

Western blot - Anti-Angiotensin II Type 1 Receptor antibody (AB124505)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (41)

Abcam product promise