Anti-Alpha B Crystallin (phospho S59) 抗体 (ab5577)
Key features and details
- Rabbit polyclonal to Alpha B Crystallin (phospho S59)
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Alpha B Crystallin (phospho S59) antibody
Alpha B Crystallin 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Alpha B Crystallin (phospho S59) -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Sheep, Rabbit, Hamster, Pig, Cynomolgus monkey
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免疫原
Synthetic peptide corresponding to Human Alpha B Crystallin aa 54-64 (phospho S59).
Sequence:FLRAPSWIDTG
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: PBS, 3% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab5577の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.
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| 特記事項 |
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WB
Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa. |
ターゲット情報
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機能
May contribute to the transparency and refractive index of the lens. -
組織特異性
Lens as well as other tissues. -
関連疾患
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. -
配列類似性
Belongs to the small heat shock protein (HSP20) family. -
細胞内局在
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. - Information by UniProt
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参照データベース
- Entrez Gene: 102128339 Cynomolgus monkey
- Entrez Gene: 1410 Human
- Entrez Gene: 100127443 Pig
- Entrez Gene: 100009295 Rabbit
- Entrez Gene: 497274 Sheep
- Omim: 123590 Human
- SwissProt: Q60HG8 Cynomolgus monkey
- SwissProt: P02511 Human
see all -
別名
- AACRYA antibody
- Alpha B crystallin antibody
- Alpha crystallin B chain antibody
see all
画像
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Western blot - Anti-Alpha B Crystallin (phospho S59) antibody (ab5577)
ab5577 at 0.5µg/ml concentration staining approximately 20 KDa Crystallin Alpha B in lane 1) phospho-alpha-B crystallin (Ser59) and lane 2) non phosphorylated alpha-B crystallin in U-251 MG (formally U-373 MG) (Human brain glioma cell line) whole cell lysate.
データシートおよび資料
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Datasheet download
参考文献 (11)
ab5577 は 11 報の論文で使用されています。
- Ueda S et al. Polo-Like Kinase 2 Plays an Essential Role in Cytoprotection against MG132-Induced Proteasome Inhibition via Phosphorylation of Serine 19 in HSPB5. Int J Mol Sci 23:N/A (2022). PubMed: 36232565
- Muraleva NA et al. SkQ1 Suppresses the p38 MAPK Signaling Pathway Involved in Alzheimer's Disease-Like Pathology in OXYS Rats. Antioxidants (Basel) 9:N/A (2020). PubMed: 32731533
- Dimauro I et al. The early response of aB-crystallin to a single bout of aerobic exercise in mouse skeletal muscles depends upon fiber oxidative features. Redox Biol 24:101183 (2019). PubMed: 30974319
- Yu W et al. Lens-specific conditional knockout of Msx2 in mice leads to ocular anterior segment dysgenesis via activation of a calcium signaling pathway. Lab Invest N/A:N/A (2019). PubMed: 30683901
- Zhang Y et al. BYD Ameliorates Oxidative Stress-Induced Myocardial Apoptosis in Heart Failure Post-Acute Myocardial Infarction via the P38 MAPK-CRYAB Signaling Pathway. Front Physiol 9:505 (2018). PubMed: 29867551
