Anti-Alpha B Crystallin (phospho S45) 抗体 (ab5598)
Key features and details
- Rabbit polyclonal to Alpha B Crystallin (phospho S45)
- Suitable for: WB
- Reacts with: Recombinant fragment
- Isotype: IgG
製品の概要
-
製品名
Anti-Alpha B Crystallin (phospho S45) antibody
Alpha B Crystallin 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Alpha B Crystallin (phospho S45) -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Recombinant fragment
交差が予測される動物種: Sheep, Rabbit, Hamster, Pig, Cynomolgus monkey
-
免疫原
Synthetic peptide corresponding to Human Alpha B Crystallin aa 1-100 (phospho S45).
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.05% Sodium azide
Constituents: 96% PBS, 3% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab5598の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa.
|
| 特記事項 |
|---|
|
WB
Use a concentration of 0.5 µg/ml. Detects a band of approximately 20 kDa. |
ターゲット情報
-
機能
May contribute to the transparency and refractive index of the lens. -
組織特異性
Lens as well as other tissues. -
関連疾患
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. -
配列類似性
Belongs to the small heat shock protein (HSP20) family. -
細胞内局在
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. - Information by UniProt
-
参照データベース
- Entrez Gene: 102128339 Cynomolgus monkey
- Entrez Gene: 100127443 Pig
- Entrez Gene: 100009295 Rabbit
- Entrez Gene: 497274 Sheep
- SwissProt: Q60HG8 Cynomolgus monkey
- SwissProt: Q7M2W6 Pig
- SwissProt: P41316 Rabbit
- SwissProt: Q5ENY9 Sheep
-
別名
- AACRYA antibody
- Alpha B crystallin antibody
- Alpha crystallin B chain antibody
see all
画像
-
Western blot - Anti-Alpha B Crystallin (phospho S45) antibody (ab5598)Western blot of recombinant bovine phospho-alpha-B crystallin (Ser45) using ab5598. Lane 1 is phospho-alpha-B crystallin (Ser45) and lane 2 is unphosphorylated alpha-B crystallin.
データシートおよび資料
-
Datasheet download
参考文献 (3)
ab5598 は 3 報の論文で使用されています。
- Muraleva NA et al. MEK1/2-ERK Pathway Alterations as a Therapeutic Target in Sporadic Alzheimer's Disease: A Study in Senescence-Accelerated OXYS Rats. Antioxidants (Basel) 10:N/A (2021). PubMed: 34208998
- Kuipers HF et al. Phosphorylation of aB-crystallin supports reactive astrogliosis in demyelination. Proc Natl Acad Sci U S A 114:E1745-E1754 (2017). PubMed: 28196893
- Tanito M et al. Diagnostic Western blot for lens-specific proteins in aqueous fluid after traumatic lens-induced uveitis. Jpn J Ophthalmol 53:436-9 (2009). PubMed: 19763765
