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AB310608

Alexa Fluor® 594 Anti-EWSR1 抗体 [EPR4647]

Alexa Fluor® 594 Anti-EWSR1 antibody [EPR4647]

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Rabbit Recombinant Monoclonal EWSR1/EWS antibody - conjugated to Alexa Fluor® 594.

別名を表示する

EWS, EWSR1, RNA-binding protein EWS, EWS oncogene, Ewing sarcoma breakpoint region 1 protein

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-EWSR1/EWS antibody [EPR4647]

  • 578 PE

    PE Anti-EWSR1 antibody [EPR4647]

  • 660 APC

    APC Anti-EWSR1 antibody [EPR4647]

  • 603 Alexa Fluor® 568

    Alexa Fluor® 568 Anti-EWSR1/EWS antibody [EPR4647]

  • HRP

    HRP Anti-EWSR1 antibody [EPR4647]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-EWSR1 antibody [EPR4647]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-EWSR1/EWS antibody [EPR4647]

  • Carrier free

    Anti-EWSR1/EWS antibody [EPR4647] - BSA and Azide free

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-EWSR1 antibody [EPR4647]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-EWSR1 antibody [EPR4647]

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR4647

アイソタイプ

IgG

標識

Alexa Fluor® 594

励起波長/蛍光波長

Ex: 590nm, Em: 617nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The EWS protein also known as EWSR1 or 2'1b1' comes from the EWSR1 gene. It is a part of the TET family of proteins and has a molecular weight of about 68 kDa. EWS is expressed widely in human tissues with high levels in the brain gonads and skeletal muscle. The protein contains an RNA-binding domain and amino acid repeats which allow it to interact with other proteins and RNA molecules.
Biological function summary

The EWS protein plays roles in various cellular processes such as transcription and RNA splicing. It can participate in forming different protein complexes which influence its function. EWS serves as a cofactor for several transcription factors and it is important in regulating the expression of genes involved in cell cycle progression and differentiation. The protein’s interaction with RNA and other molecules highlights its multifunctional nature within cellular environments.

Pathways

EWS engages in pathways like the regulation of transcription and RNA processing. It closely associates with proteins involved in gene expression surveillance such as the RNA polymerase II which is significant for transcription activities. EWS partners with proteins such as FUS and TAF15 which are essential parts of transcription regulation networks. These interactions place EWS in a central role in cellular regulatory machinery.

EWS is notably linked to Ewing sarcoma and neurodegenerative diseases. In Ewing sarcoma EWS forms fusion proteins like EWS-FLI1 by translocation events which lead to tumor formation. This fusion protein acts abnormally in transcription regulation driving oncogenic pathways. EWS's interaction with proteins like FUS and TAF15 also relate it to certain neurodegenerative conditions indicating its importance in both cancer and neurobiology.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.
See full target information EWSR1
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB240055

Anti-EWSR1/EWS antibody [EPR4647] - BSA and Azide free

primary-antibodies

ewsr1-ews-antibody-epr4647-bsa-and-azide-free-ab240055

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(0 reviews)

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