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リコンビナントRabMAb

Alexa Fluor® 594 Anti-CD45 抗体 [EP322Y] (ab303598)

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Alexa Fluor® 594 Anti-CD45 antibody [EP322Y] (AB303598)

    Key features and details

    • Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
    • Alexa Fluor® 594 Rabbit monoclonal [EP322Y] to CD45
    • Suitable for: ICC/IF, Flow Cyt (Intra)
    • Reacts with: Human
    • Conjugation: Alexa Fluor® 594. Ex: 590nm, Em: 617nm

    Conjugates logo Related conjugates and formulations

    Alexa Fluor® 488 Alexa Fluor® 647 APC Carrier Free PE PerCP Unconjugated

    製品の概要

    • 製品名

      Alexa Fluor® 594 Anti-CD45 antibody [EP322Y]
      CD45 一次抗体 製品一覧

    • 製品の詳細

      Alexa Fluor® 594 Rabbit monoclonal [EP322Y] to CD45

    • 由来種

      Rabbit

    • 標識

      Alexa Fluor® 594. Ex: 590nm, Em: 617nm

    • 特異性

      Anti-CD45 antibody [EP322Y] (ab40763) recognizes cytoplasmic domain of CD45.

    • アプリケーション

      適用あり: ICC/IF, Flow Cyt (Intra)more details

    • 種交差性

      交差種: Human

    • 免疫原

      Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.

    • ポジティブ･コントロール

      • Flow Cyt (Intra): Jurkat and Human PBMCs. ICC/IF: Jurkat cells.

    • 特記事項

      This product is a recombinant monoclonal antibody, which offers several advantages including:

      • - High batch-to-batch consistency and reproducibility
      • - Improved sensitivity and specificity
      • - Long-term security of supply
      • - Animal-free production
      For more information see here.

      Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

      Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com.

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab303598の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    ICC/IF
    Use a concentration of 5 µg/ml.
    Flow Cyt (Intra)
    1/2500 - 1/12500.
    特記事項
    ICC/IF
    Use a concentration of 5 µg/ml.
    Flow Cyt (Intra)
    1/2500 - 1/12500.

    ターゲット情報

    • 機能

      Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN.

    • 関連疾患

      Defects in PTPRC are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development.
      Genetic variations in PTPRC are involved in multiple sclerosis susceptibility (MS) [MIM:126200]. MS is a neurodegenerative disorder characterized by the gradual accumulation of focal plaques of demyelination particularly in the periventricular areas of the brain. Peripheral nerves are not affected. Onset usually in third or fourth decade with intermittent progression over an extended period. The cause is still uncertain.

    • 配列類似性

      Belongs to the protein-tyrosine phosphatase family. Receptor class 1/6 subfamily.
      Contains 2 fibronectin type-III domains.
      Contains 2 tyrosine-protein phosphatase domains.

    • ドメイン

      The first PTPase domain interacts with SKAP1.

    • 翻訳後修飾

      Heavily N- and O-glycosylated.

    • 細胞内局在

      Membrane. Membrane raft. Colocalized with DPP4 in membrane rafts.
    • Information by UniProt

    • 参照データベース

      • 別名

        • B220 antibody
        • CD 45 antibody
        • CD45 antibody
        • CD45 antigen antibody
        • CD45R antibody
        • GP180 antibody
        • L-CA antibody
        • LCA antibody
        • Leukocyte common antigen antibody
        • loc antibody
        • Ly-5 antibody
        • LY5 antibody
        • Ly5, homolog of antibody
        • Lyt-4 antibody
        • OTTHUMP00000033813 antibody
        • OTTHUMP00000033816 antibody
        • OTTHUMP00000033817 antibody
        • OTTHUMP00000038574 antibody
        • Protein tyrosine phosphatase receptor type c polypeptide antibody
        • Protein tyrosine phosphatase, receptor type C antibody
        • protein tyrosine phosphatase, receptor type, C antibody
        • Protein tyrosine phosphatase, receptor type, c polypeptide antibody
        • Ptprc antibody
        • PTPRC_HUMAN antibody
        • Receptor-type tyrosine-protein phosphatase C antibody
        • T200 antibody
        • T200 glycoprotein antibody
        • T200 leukocyte common antigen antibody
        see all

      画像

      • Alexa Fluor® 594 Anti-CD45 antibody [EP322Y] (AB303598)
        Alexa Fluor® 594 Anti-CD45 antibody [EP322Y] (AB303598)

      プロトコール

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      参考文献 (0)

      ab303598 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab303598 は論文での使用が確認できていません。

      レビューと Q&A

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