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AB312436

Alexa Fluor® 568 Anti-Wnt3a 抗体 [EPR21889]

Alexa Fluor® 568 Anti-Wnt3a antibody [EPR21889]

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Rabbit Recombinant Monoclonal WNT3A antibody - conjugated to Alexa Fluor® 568.

別名を表示する

Protein Wnt-3a, WNT3A

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-Wnt3a antibody [EPR21889]

  • 578 PE

    PE Anti-Wnt3a antibody [EPR21889]

  • 660 APC

    APC Anti-Wnt3a antibody [EPR21889]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Wnt3a antibody [EPR21889]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Wnt3a antibody [EPR21889]

  • HRP

    HRP Anti-Wnt3a antibody [EPR21889]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Wnt3a antibody [EPR21889]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Wnt3a antibody [EPR21889]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Wnt3a antibody [EPR21889]

  • Carrier free

    Anti-Wnt3a antibody [EPR21889] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR21889

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

Unsuitable for human IHC-P. Rat species is recommended based on IHC result. We do not guarantee western blot for rat.

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Wnt3a protein also known as Wingless-related integration site 3a is a member of the Wnt family of proteins. It has a molecular mass of approximately 38 kDa. Wnt3a is a secreted glycoprotein that plays a mechanical role in cell signaling. It is expressed in various tissues including the neural tube somites and limb buds in the developing embryo. The protein functions by binding to Frizzled receptors on the cell surface initiating a signaling cascade that influences cellular behaviors.
Biological function summary

Wnt3a plays a critical role in embryonic development and cell proliferation. As part of a larger complex it partners with other signaling molecules to ensure proper cellular communication. Wnt3a is important in patterning during embryogenesis influencing processes like axis formation and organogenesis. Its expression impacts the development of skeletal structures by regulating the differentiation and proliferation of precursor cells.

Pathways

Wnt3a is an integral component of the canonical Wnt/β-catenin signaling pathway which regulates gene expression essential for cell fate decisions. This pathway is activated when Wnt3a binds to the Frizzled and LRP5/6 receptor complex stabilizing β-catenin in the cytosol. Glycogen synthase kinase 3 beta (GSK-3β) and Adenomatosis polyposis coli (APC) are key proteins involved which help mediate the signal to downstream targets involved in cell growth and development.

Wnt3a has significant associations with cancer and bone developmental disorders. Dysregulation of the Wnt3a signaling pathway can lead to tumorigenesis due to unchecked cellular proliferation and survival. In cancer components like β-catenin become targets for therapeutic interventions. In bone disorders improperly regulated Wnt3a expression can result in conditions like osteoporosis where the balance between bone formation and resorption is disrupted. FGFR2 a protein involved in skeletal abnormalities often interacts with dysregulated Wnt3a signaling highlighting its importance in bone health.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (PubMed : 20093360, PubMed : 21244856, PubMed : 24841207, PubMed : 26902720). Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). Mediates self-renewal of the stem cells at the bottom on intestinal crypts (in vitro) (PubMed : 26902720).
See full target information WNT3A
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB234099

Anti-Wnt3a antibody [EPR21889] - BSA and Azide free

primary-antibodies

wnt3a-antibody-epr21889-bsa-and-azide-free-ab234099

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(1 reviews)

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