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AB312402

Alexa Fluor® 568 Anti-Transcription factor AP-2-alpha 抗体 [EPR2688(2)]

Alexa Fluor® 568 Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

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Rabbit Recombinant Monoclonal Transcription factor AP-2-alpha antibody - conjugated to Alexa Fluor® 568.

別名を表示する

AP2TF, TFAP2, TFAP2A, Transcription factor AP-2-alpha, AP2-alpha, AP-2 transcription factor, Activating enhancer-binding protein 2-alpha, Activator protein 2, AP-2

関連する標識済み抗体及び組成の異なる製品 (11)

  • Unconjugated

    Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • 660 APC

    APC Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • HRP

    HRP Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • Alkaline Phosphatase

    AP Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • 578 PE

    PE Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)]

  • Carrier free

    Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR2688(2)

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Transcription factor AP-2-alpha also known as TFAP2A or AP-2 is a protein acting as an important regulator in cellular processes. It weighs approximately 52 kDa. TFAP2A is known for its role in binding specific DNA sequences to regulate target gene transcription. It expresses highly in neural crest-derived tissues as well as in the placenta breast and skin. This transcription factor plays an essential role in embryonic development cell proliferation and differentiation.
Biological function summary

TFAP2A contributes significantly to the regulation of gene expression involved in essential developmental and cellular processes. It acts as part of a complex with other transcription factors allowing it to coordinate the expression of a variety of genes linked to cell growth and apoptosis. AP-2 also regulates genes involved in neural development and skin morphogenesis. Its interaction with other factors such as AP-2γ and AP-2β enhances its functionality indicating a complex mechanism of action.

Pathways

TFAP2A engages in critical signalling circuits such as the MAPK and Wnt pathways which are essential for cell cycle regulation and embryonic development. Within these pathways related proteins like AP-2γ and AP-594 interact with TFAP2A further illustrating its role in signal transduction. These relationships highlight the importance of TFAP2A in orchestrating cellular responses to growth signals and environmental cues.

TFAP2A has links to a range of pathological conditions including cancer and neural crest-related disorders. In melanoma for example TFAP2A's regulatory role affects genes associated with tumor growth and metastasis. The protein's interaction with other transcription factors like AP-647 may influence cancer progression and therapy response. Additionally the dysregulation of TFAP2A affects neural crest development potentially leading to congenital disorders. Understanding these interactions assists in unraveling the molecular basis of such diseases and informs therapeutic strategies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.
See full target information TFAP2A
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB236043

Anti-Transcription factor AP-2-alpha antibody [EPR2688(2)] - BSA and Azide free

primary-antibodies

transcription-factor-ap-2-alpha-antibody-epr26882-bsa-and-azide-free-ab236043

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