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AB312629

Alexa Fluor® 568 Anti-Thioredoxin 2 抗体 [EPR15225]

Alexa Fluor® 568 Anti-Thioredoxin 2 antibody [EPR15225]

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Rabbit Recombinant Monoclonal Thioredoxin 2 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

TRX2, TXN2, MTRX, Mt-Trx, Thioredoxin-2

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-Thioredoxin 2 antibody [EPR15225]

  • 578 PE

    PE Anti-Thioredoxin 2 antibody [EPR15225]

  • 660 APC

    APC Anti-Thioredoxin 2 antibody [EPR15225]

  • HRP

    HRP Anti-Thioredoxin 2 antibody [EPR15225]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Thioredoxin 2 antibody [EPR15225]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Thioredoxin 2 antibody [EPR15225]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Thioredoxin 2 antibody [EPR15225]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Thioredoxin 2 antibody [EPR15225]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Thioredoxin 2 antibody [EPR15225]

  • Carrier free

    Anti-Thioredoxin 2 antibody [EPR15225] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR15225

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Thioredoxin 2 also known as TXN2 is a protein that functions mainly as an oxidoreductase. It facilitates the reduction of other proteins through cysteine thiol-disulfide exchange which is important for maintaining cellular redox balance. This protein exists in the mitochondria where it is expressed ubiquitously across tissues. Thioredoxin 2 has a molecular mass of approximately 18 kDa. The presence of TXN2 in all cellular compartments suggests its importance in various cellular processes involving oxidative stress response.
Biological function summary

Thioredoxin 2 participates in regulating mitochondrial redox homeostasis ensuring the protection of mitochondrial DNA against oxidative damage. It acts as a part of the mitochondrial thioredoxin system which includes thioredoxin reductase and NADPH as components. This system is important for the control of mitochondrial reactive oxygen species (ROS) and supports mitochondrial function by facilitating the synthesis of deoxyribonucleotides. The protein therefore plays an important role in cellular antioxidant defenses and in modulating mitochondrial apoptotic pathways.

Pathways

The involvement of Thioredoxin 2 is pivotal in several cellular signaling cascades including the antioxidant defense and apoptosis pathways. Within the redox signaling pathways TXN2 works in conjunction with cytochrome c and caspases to regulate apoptosis and prevent uncontrolled cell death. In pathways related to cellular oxidative stress Thioredoxin 2 interacts closely with glutathione to mediate cellular responses to oxidative damage maintaining balance between the production and removal of ROS.

The dysregulation of Thioredoxin 2 correlates with various human conditions such as cancer and neurodegenerative diseases. In cancer alterations in TXN2 levels can affect cell survival and proliferation often by interacting with other antioxidant proteins like peroxiredoxins. For neurodegenerative diseases an imbalance in Thioredoxin 2 activity contributes to neuronal damage through disrupted oxidative stress regulation. This highlights TXN2's potential as a therapeutic target for disorders connected to oxidative stress imbalances.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
See full target information TXN2
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB240292

Anti-Thioredoxin 2 antibody [EPR15225] - BSA and Azide free

primary-antibodies

thioredoxin-2-antibody-epr15225-bsa-and-azide-free-ab240292

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