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AB312350

Alexa Fluor® 568 Anti-STAT6 (phospho Y641) 抗体 [EPR22599-78]

Alexa Fluor® 568 Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

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Rabbit Recombinant Monoclonal STAT6 phospho Y641 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

Signal transducer and transcription activator 6, Stat6

関連する標識済み抗体及び組成の異なる製品 (9)

  • Unconjugated

    Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • 578 PE

    PE Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • 660 APC

    APC Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • HRP

    HRP Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-STAT6 (phospho Y641) antibody [EPR22599-78]

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR22599-78

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

STAT6 is activated via phosphorylation at Tyr641 and is required for responsiveness to IL-4 and IL-13.

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下記製品にもご興味をお持ちいただけるかもしれません:

AB126430

STAT6 (Tyr641) In-Cell ELISA Kit

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0 Reviews

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こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

お客様の実験に適するかご確認いただくため、必ず製品データシートをご確認いただくことをお勧めいたします。ご不明点等ございましたら、テクニカルサポートチームまでお問い合わせください。

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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

STAT6 also known as Signal Transducer and Activator of Transcription 6 is a transcription factor with a mass of around 94 kDa. This protein is an important component in the signaling pathways that respond to cytokines especially those of the IL-4 and IL-13 receptors. STAT6 mainly expresses in immune cells including T cells B cells and macrophages. It exists in the cytoplasm until the cytokine stimulation prompts its phosphorylation and translocation to the nucleus where it influences gene expression.
Biological function summary

STAT6 plays a central role in the development and function of Th2 cells a subset of T helper cells. The protein controls genes linked to the immune response and inflammation such as IL-4 and IL-13 by binding to specific DNA sequences as part of the transcriptional complex. These processes are critical for antibody class switching in B cells and also for regulating the differentiation of T cells which are processes important in defending against parasitic infections and are linked to allergies.

Pathways

STAT6 functions mainly in the JAK-STAT signaling pathway a pathway important for transmitting information from chemical signals outside cells to the cell nucleus resulting in DNA transcription. Within this pathway STAT6 works closely with JAK1 and JAK3 kinases which phosphorylate STAT6 enabling its activation. The protein also connects with other members of the STAT family like STAT1 and STAT3 during overlapping signaling processes.

STAT6 has associations with asthma and certain types of cancer such as colorectal cancer. In asthma STAT6 influences the production of IgE and eosinophilic inflammation often connected to allergic responses. Meanwhile STAT6 promotes tumorigenesis in some cancers by regulating genes responsible for cell survival and proliferation. It connects with proteins like IL-4 and IL-13 in these disorders which suggests potential therapeutic targets for treatment.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Carries out a dual function : signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
See full target information Stat6 phospho Y641
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB263950

Anti-STAT6 (phospho Y641) antibody [EPR22599-78] - BSA and Azide free

primary-antibodies

stat6-phospho-y641-antibody-epr22599-78-bsa-and-azide-free-ab263950

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(0 reviews)

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