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AB312619

Alexa Fluor® 568 Anti-PPP1R1A 抗体 [EP902Y]

Alexa Fluor® 568 Anti-PPP1R1A antibody [EP902Y]

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Rabbit Recombinant Monoclonal PPP1R1A antibody - conjugated to Alexa Fluor® 568.

別名を表示する

IPP1, PPP1R1A, Protein phosphatase 1 regulatory subunit 1A, Protein phosphatase inhibitor 1, I-1, IPP-1

関連する標識済み抗体及び組成の異なる製品 (10)

  • 578 PE

    PE Anti-PPP1R1A antibody [EP902Y]

  • 660 APC

    APC Anti-PPP1R1A antibody [EP902Y]

  • HRP

    HRP Anti-PPP1R1A antibody [EP902Y]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-PPP1R1A antibody [EP902Y]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-PPP1R1A antibody [EP902Y]

  • Unconjugated

    Anti-PPP1R1A antibody [EP902Y]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-PPP1R1A antibody [EP902Y]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-PPP1R1A antibody [EP902Y]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-PPP1R1A antibody [EP902Y]

  • Carrier free

    Anti-PPP1R1A antibody [EP902Y] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EP902Y

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The protein phosphatase 1 regulatory inhibitor subunit 1A also known as PPP1R1A or inhibitor-1 (I-1) plays a significant role in cellular regulation as a phosphatase inhibitor. Mechanically it regulates the activity of protein phosphatase 1 (PP1) an essential enzyme in various cellular processes. Its molecular weight is approximately 19 kDa. PPP1R1A is expressed in many tissues showing notable levels in cardiac and skeletal muscle where it helps modulate responses to various stimuli.
Biological function summary

PPP1R1A modulates signaling pathways by influencing the dephosphorylation of substrates which is a critical step in signal transduction. It is not typically part of a complex but interacts closely with protein phosphatase 1. This interaction allows for the effective regulation of phosphorylation states within cells impacting cell cycle control muscle contraction glycogen metabolism and more. Its regulatory capabilities are important for maintaining cellular homeostasis.

Pathways

The regulatory activities of PPP1R1A significantly impact the cAMP signaling pathway and the regulation of glycogen metabolism. Within the cAMP pathway PPP1R1A regulates the activity of PP1 influencing processes like muscle contraction and gene expression. It interacts with proteins such as PKA which phosphorylates PPP1R1A activating its inhibitory function. This regulation affects downstream cellular activities by modulating phosphorylation levels of key substrates within these pathways.

Alterations in PPP1R1A expression or function have implications in cardiac diseases and diabetes. Increased or decreased activity of PPP1R1A can disrupt normal heart function due to its regulatory role in cardiac muscle contraction. Altered regulation within the cAMP and glycogen metabolism pathways can contribute to metabolic disorders like diabetes. Interactions with proteins such as PP1 and PKA are critical for these conditions highlighting PPP1R1A's role in disease progression and potential therapeutic targeting.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
See full target information PPP1R1A
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB247299

Anti-PPP1R1A antibody [EP902Y] - BSA and Azide free

primary-antibodies

ppp1r1a-antibody-ep902y-bsa-and-azide-free-ab247299

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