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AB312762

Alexa Fluor® 568 Anti-PMP22 抗体 [EPR23112-110]

Alexa Fluor® 568 Anti-PMP22 antibody [EPR23112-110]

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Rabbit Recombinant Monoclonal PMP22 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

GAS3, PMP22, Peripheral myelin protein 22, PMP-22, Growth arrest-specific protein 3, GAS-3

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-PMP22 antibody [EPR23112-110]

  • 660 APC

    APC Anti-PMP22 antibody [EPR23112-110]

  • HRP

    HRP Anti-PMP22 antibody [EPR23112-110]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-PMP22 antibody [EPR23112-110]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-PMP22 antibody [EPR23112-110]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-PMP22 antibody [EPR23112-110]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-PMP22 antibody [EPR23112-110]

  • 578 PE

    PE Anti-PMP22 antibody [EPR23112-110]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-PMP22 antibody [EPR23112-110]

  • Carrier free

    Anti-PMP22 antibody [EPR23112-110] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR23112-110

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The 'PMP22 protein' also known as Peripheral Myelin Protein 22 is an essential component of the myelin sheath in the peripheral nervous system. It has a molecular weight of approximately 22 kDa. The protein is highly expressed in Schwann cells which are responsible for forming myelin around peripheral nerves. PMP22 contains four transmembrane domains playing a role in its structural function in the membrane.
Biological function summary

The 'PMP22' serves an important role in maintaining the integrity and functionality of the myelin sheath contributing to efficient nerve conduction. It is not typically part of a complex but interacts with other myelin proteins to support myelin compaction and stability. The protein's presence affects the cell cycle and myelination process important for the normal functioning of the peripheral nervous system.

Pathways

'PMP22 protein' plays roles in the Schwann cell differentiation and myelination pathways. It maintains correct peripheral nerve structure and function with connections to proteins such as MPZ (Myelin Protein Zero) which are also integral for proper nerve insulation. There are specific pathways where PMP22 downregulation or overexpression impacts the normal myelination cycle significant for peripheral nerve health.

'PMP 22' mutations or overexpression relate to Charcot-Marie-Tooth disease type 1A and Hereditary Neuropathy with Liability to Pressure Palsies (HNPP). These conditions arise from gene dosage changes affecting nerve function where altered PMP22 protein levels lead to defective myelin formation. Interaction between PMP22 and proteins like connexin 32 shows further ties to demyelinating neuropathies emphasizing the gene-protein network involved in these disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Might be involved in growth regulation, and in myelinization in the peripheral nervous system.
See full target information PMP22
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB270407

Anti-PMP22 antibody [EPR23112-110] - BSA and Azide free

primary-antibodies

pmp22-antibody-epr23112-110-bsa-and-azide-free-ab270407

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(0 reviews)

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