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AB312613

Alexa Fluor® 568 Anti-PCK2 抗体 [EPR14224] - C-terminal

Alexa Fluor® 568 Anti-PCK2 antibody [EPR14224] - C-terminal

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Rabbit Recombinant Monoclonal PCK2 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

PEPCK2, PCK2, PEPCK-M, mtPCK2

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-PCK2 antibody [EPR14224] - C-terminal

  • 660 APC

    APC Anti-PCK2 antibody [EPR14224] (C-terminal)

  • HRP

    HRP Anti-PCK2 antibody [EPR14224] (C-terminal)

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-PCK2 antibody [EPR14224] - C-terminal

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-PCK2 antibody [EPR14224] - C-terminal

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-PCK2 antibody [EPR14224] - C-terminal

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-PCK2 antibody [EPR14224] - C-terminal

  • 578 PE

    PE Anti-PCK2 antibody [EPR14224] (C-terminal)

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-PCK2 antibody [EPR14224] - C-terminal

  • Carrier free

    Anti-PCK2 antibody [EPR14224] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR14224

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Phosphoenolpyruvate carboxykinase 2 (PCK2) also known as mitochondrial PEPCK is an enzyme that plays an important role in gluconeogenesis. It catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the mitochondria. PCK2 has a molecular mass of approximately 69 kDa and is expressed mainly in tissues that require high energy production such as the liver and kidney. Despite its vital function in energy metabolism PCK2 is also present in other metabolic tissues.
Biological function summary

PCK2 contributes to the regulation of glucose homeostasis. It achieves this by being a part of the gluconeogenic pathway working in concert with cytosolic PCK1. PCK2 does not work alone; it integrates into a larger metabolic framework that includes various enzymes essential for converting different substrates into glucose. This enzyme is notably active during fasting states or periods of high energy demands such as intense exercise ensuring a continuous supply of glucose to maintain cellular functions.

Pathways

PCK2 plays an important role in the gluconeogenesis and TCA cycle. The gluconeogenesis pathway allows the liver and kidney to produce glucose from non-carbohydrate substrates which is integral during fasting and low-carbohydrate diet. It is functionally linked with other key enzymes like pyruvate carboxylase in converting pyruvate to glucose and also cooperates with malate dehydrogenase in the TCA cycle. This cooperation ensures efficient energy production and conversion balance in the cell.

PCK2 expression is linked to type 2 diabetes and certain cancers. In type 2 diabetes altered PCK2 activity impacts glucose production contributing to hyperglycemia. Studies have shown that its dysregulation may correlate with insulin resistance a characteristic feature of diabetes. In cancer particularly some forms of breast cancer the interplay between PCK2 and oncogenes like KRAS can affect tumor metabolism promoting the adaptation of cancer cells to the energy-demanding environment.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (PubMed : 28955899). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed : 28955899).
See full target information PCK2
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB236129

Anti-PCK2 antibody [EPR14224] - BSA and Azide free

primary-antibodies

pck2-antibody-epr14224-bsa-and-azide-free-ab236129

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