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AB312753

Alexa Fluor® 568 Anti-pan Cadherin 抗体 [EPR1792Y] - Intercellular Junction Marker

Alexa Fluor® 568 Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

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Rabbit Recombinant Monoclonal N Cadherin antibody - conjugated to Alexa Fluor® 568. Intercellular Junction marker.

別名を表示する

CD325, CDHN, NCAD, CDH2, Cadherin-2, CDw325, Neural cadherin, N-cadherin

関連する標識済み抗体及び組成の異なる製品 (11)

  • 578 PE

    PE Anti-pan Cadherin - Intercellular Junction Marker antibody [EPR1792Y]

  • 660 APC

    APC Anti-pan Cadherin - Intercellular Junction Marker antibody [EPR1792Y]

  • HRP

    HRP Anti-pan Cadherin - Intercellular Junction Marker antibody [EPR1792Y]

  • Unconjugated

    Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

  • Alkaline Phosphatase

    Alkaline Phosphatase Anti-pan Cadherin antibody [EPR1792Y]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

  • Carrier free

    Anti-pan Cadherin antibody [EPR1792Y] - BSA and Azide free

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-pan Cadherin antibody [EPR1792Y] - Intercellular Junction Marker

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR1792Y

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

The immunogen used for this product shares 100% homology with N-cadherin, 100% homology with R-cadherin, 93% homology to K-cadherin, 93% homology to P-cadherin, 93% homology to E-cadherin, and 73% homology to VE-cadherin. Cross-reactivities with these proteins have not been confirmed experimentally.

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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

P cadherin also known as cadherin-3 or CDH3 is a calcium-dependent cell-cell adhesion glycoprotein. Scientists often refer to it as P-cadherin and it belongs to the cadherin protein family which includes other members like E-cadherin and N-cadherin. The molecular mass of P cadherin is approximately 120 kDa. It is mainly expressed in epithelial tissues including the basal side of scalp and mammary glands acting as an important mediator in maintaining tissue integrity.
Biological function summary

P cadherin plays an important role in facilitating cell adhesion and establishing proper tissue architecture. It often forms part of a larger complex by interacting with catenins including beta-catenin which helps link the cadherin itself to the actin cytoskeleton. Through these interactions P cadherin influences processes such as cell sorting boundary formation and cell polarization essential for embryonic development and tissue homeostasis.

Pathways

Cell adhesion and signal transduction are influenced by P cadherin through its involvement in the Wnt signaling pathway and cadherin-catenin complex. Within the Wnt pathway P cadherin interacts with other key proteins such as beta-catenin which transduces signals leading to gene expression changes. This interaction is important for controlling cellular processes including cell proliferation and differentiation.

P cadherin associates with various cancer types particularly breast and prostate cancers. Altered expression or dysfunction of P cadherin correlates with tumor progression and metastasis. Its interaction with E-cadherin may also contribute to the development and progression of skin disease hypotrichosis with juvenile macular dystrophy. Understanding the role of P cadherin within these contexts offers potential for developing targeted therapies and diagnostic tools.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion by dimerization with a CDH2 chain from another cell. Cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone : upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. Plays a role in cell-to-cell junction formation between pancreatic beta cells and neural crest stem (NCS) cells, promoting the formation of processes by NCS cells (By similarity). Required for proper neurite branching. Required for pre- and postsynaptic organization (By similarity). CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
See full target information CDH2
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