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AB312963

Alexa Fluor® 568 Anti-p75 NGF Receptor 抗体 [EP1039Y]

Alexa Fluor® 568 Anti-p75 NGF Receptor antibody [EP1039Y]

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Rabbit Recombinant Monoclonal p75 NGF Receptor antibody - conjugated to Alexa Fluor® 568.

別名を表示する

CD271, TNFRSF16, NGFR, Tumor necrosis factor receptor superfamily member 16, Gp80-LNGFR, Low affinity neurotrophin receptor p75NTR, Low-affinity nerve growth factor receptor, Low-affinity nerve growth factor receptor p75NGFR, Low-affinity nerve growth factor receptor p75NGR, p75 ICD, NGF receptor

関連する標識済み抗体及び組成の異なる製品 (10)

  • Carrier free

    Anti-p75 NGF Receptor antibody [EP1039Y] - Low endotoxin, Azide free

  • Unconjugated

    Anti-p75 NGF Receptor antibody [EP1039Y]

  • Carrier free

    Anti-p75 NGF Receptor antibody [EP1039Y] - BSA and Azide free

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-p75 NGF Receptor antibody [EP1039Y]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-p75 NGF Receptor antibody [EP1039Y]

  • 578 PE

    PE Anti-p75 NGF Receptor antibody [EP1039Y]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-p75 NGF Receptor antibody [EP1039Y]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-p75 NGF Receptor antibody [EP1039Y]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-p75 NGF Receptor antibody [EP1039Y]

  • 660 APC

    APC Anti-p75 NGF Receptor antibody [EP1039Y]

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EP1039Y

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat.

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下記製品にもご興味をお持ちいただけるかもしれません:

AB155436

Human NGF R ELISA Kit (CD271)

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0 Reviews

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こちらの製品も推奨する理由

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The p75 NGF receptor also known as p75 NGFR or anti-NTR is a transmembrane protein with a molecular mass of approximately 75 kDa. It is a member of the tumor necrosis factor receptor superfamily. This receptor is widely expressed in the nervous system particularly in neurons glial cells and Schwann cells. The p75 receptor primarily binds to neurotrophins such as nerve growth factor (NGF) influencing neuronal survival apoptosis and growth.
Biological function summary

The p75 receptor functions as an important part of a signaling complex that mediates diverse cellular responses. It often forms complexes with other receptors like TrkA but can also signal independently. In particular the p75 protein can form a biological chimera with different co-receptors influencing its downstream effects. This makes it significant in processes like apoptosis and neuronal differentiation as well as influencing neurotrophin-mediated signaling.

Pathways

The p75 receptor plays an important role in pathways involving neuronal survival and apoptosis. One key pathway involves the nerve growth factor (NGF) signaling pathway where p75 collaborates with Trk receptors enhancing or inhibiting NGF signaling based on cellular context. Another pathway is the JNK signaling pathway where the p75 receptor interacts with proteins like sortilin contributing to apoptosis and stress responses in neurons. These interactions determine the outcome of neurotrophic signaling highlighting its role in cell fate decisions.

P75 receptor is associated with several neurodegenerative conditions and cancers. Its involvement in Alzheimer's disease is significant because altered p75 expression and function can contribute to neurodegeneration through apoptosis pathways. This receptor is also linked to glioblastoma where it might promote tumor progression in coordination with proteins such as sortilin. These links make p75 receptor a target of interest for therapeutic intervention in these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed : 24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed : 26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed : 23785138).
See full target information NGFR
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