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AB312390

Alexa Fluor® 568 Anti-NDRG2 抗体 [EPR11910]

Alexa Fluor® 568 Anti-NDRG2 antibody [EPR11910]

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Rabbit Recombinant Monoclonal NDRG2 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

KIAA1248, SYLD, NDRG2, Protein NDRG2, N-myc downstream-regulated gene 2 protein, Protein Syld709613

関連する標識済み抗体及び組成の異なる製品 (9)

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-NDRG2 antibody [EPR11910]

  • Unconjugated

    Anti-NDRG2 antibody [EPR11910]

  • 578 PE

    PE Anti-NDRG2 antibody [EPR11910]

  • 660 APC

    APC Anti-NDRG2 antibody [EPR11910]

  • HRP

    HRP Anti-NDRG2 antibody [EPR11910]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-NDRG2 antibody [EPR11910]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-NDRG2 antibody [EPR11910]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-NDRG2 antibody [EPR11910]

  • Carrier free

    Anti-NDRG2 antibody [EPR11910] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR11910

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

The mouse and rat recommendation is based on the WB results. We do not guarantee IHC-P for mouse and rat.This antibody does not cross-react with human NDRG4.

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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

NDRG2 also known as N-myc downstream-regulated gene 2 is a protein with a molecular mass of approximately 41.5 kDa. It plays an important role in cellular stress responses and cell growth regulation. NDRG2 is typically expressed in various tissues especially in the liver heart and brain. Its expression suggests its involvement in diverse physiological processes which is supported by its presence across multiple cell types.
Biological function summary

NDRG2 influences cellular processes related to oxidative stress and differentiation. It is not known as part of a major protein complex but it interacts with other proteins to modulate cellular environments. NDRG2 acts as a tumor suppressor and can affect cell cycle regulation. It also plays roles in apoptosis and responses to DNA damage essential for maintaining cell health and function.

Pathways

NDRG2 engages in essential cellular processes. It is involved in the PI3K/Akt and MAPK pathways both of which regulate cell proliferation and survival. NDRG2 interacts with proteins such as PTEN and Akt where it can modulate their activities. Through this regulation it impacts cellular responses to growth factors and contributes to maintaining cellular homeostasis.

Altered NDRG2 expression links with cancer and neurodegenerative diseases. In cancer its tumor suppressor role involves interactions with proteins such as p53 impacting cell survival pathways. In neurodegenerative diseases changes in NDRG2 expression can affect neuronal cell health and may interact with proteins like tau influencing disease progression. Understanding NDRG2's function helps in exploring therapeutic targets for these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation.
See full target information NDRG2
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB240181

Anti-NDRG2 antibody [EPR11910] - BSA and Azide free

primary-antibodies

ndrg2-antibody-epr11910-bsa-and-azide-free-ab240181

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