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AB312643

Alexa Fluor® 568 Anti-INPP4B 抗体 [EPR3108Y]

Alexa Fluor® 568 Anti-INPP4B antibody [EPR3108Y]

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Rabbit Recombinant Monoclonal INPP4B antibody - conjugated to Alexa Fluor® 568.

別名を表示する

Inositol polyphosphate 4-phosphatase type II, INPP4B

関連する標識済み抗体及び組成の異なる製品 (10)

  • 578 PE

    PE Anti-INPP4B antibody [EPR3108Y]

  • 660 APC

    APC Anti-INPP4B antibody [EPR3108Y]

  • HRP

    HRP Anti-INPP4B antibody [EPR3108Y]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-INPP4B antibody [EPR3108Y]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-INPP4B antibody [EPR3108Y]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-INPP4B antibody [EPR3108Y]

  • Unconjugated

    Anti-INPP4B antibody [EPR3108Y]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-INPP4B antibody [EPR3108Y]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-INPP4B antibody [EPR3108Y]

  • Carrier free

    Anti-INPP4B antibody [EPR3108Y] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR3108Y

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

INPP4B also known as inositol polyphosphate-4-phosphatase type II has a molecular mass of approximately 105 kDa. This enzyme primarily localizes in the cytoplasm but also presents in the nucleus. It catalyzes the hydrolysis of the 4-phosphate group from phosphoinositides converting phosphatidylinositol (34)-bisphosphate (PI(34)P2) to phosphatidylinositol 3-phosphate (PI3P). INPP4B expression is noticeable in various tissues including the prostate thyroid and breast suggesting its diverse roles in different physiological processes.
Biological function summary

INPP4B participates in regulating intracellular signaling pathways and maintaining cellular homeostasis. It is a negative regulator of the PI3K/AKT signaling cascade a critical pathway controlling cell growth proliferation survival and metabolism. INPP4B acts as a tumor suppressor modulating signals that impact cellular transformation and tumorigenesis. While not known to form a complex itself it indirectly influences complexes within the cascade through its regulatory functions.

Pathways

INPP4B contributes to the PI3K/AKT and mTOR pathways. It regulates PI3K/AKT signaling by decreasing levels of PI(34)P2 therefore modulating AKT activity. This action makes it an essential component in controlling mTOR signaling which affects protein synthesis and autophagy. INPP4B closely interacts with other signaling proteins like PTEN also a phosphatase which further lowers PI3K signaling by dephosphorylating PI(345)P3 to PI(45)P2.

INPP4B has notable links to cancer and insulin resistance. In some cancers like breast and prostate reduced INPP4B expression correlates with increased aggressive phenotypic markers and poor outcomes indicating its tumor-suppressive role. Its regulation of the PI3K/AKT pathway connects it to insulin signaling where dysregulated pathways can lead to insulin resistance a critical factor in type 2 diabetes. INPP4B interacts with proteins involved in these diseases like AKT and PTEN which further influence and exacerbate the pathology in these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed : 24070612, PubMed : 24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed : 24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed : 19647222, PubMed : 24070612).
See full target information INPP4B
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB247515

Anti-INPP4B antibody [EPR3108Y] - BSA and Azide free

primary-antibodies

inpp4b-antibody-epr3108y-bsa-and-azide-free-ab247515

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(0 reviews)

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