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AB312681

Alexa Fluor® 568 Anti-Geminin 抗体 [EPR23754-87]

Alexa Fluor® 568 Anti-Geminin antibody [EPR23754-87]

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Rabbit Recombinant Monoclonal Geminin antibody - conjugated to Alexa Fluor® 568.

別名を表示する

Geminin, Gmnn

関連する標識済み抗体及び組成の異なる製品 (10)

  • 660 APC

    APC Anti-Geminin antibody [EPR23754-87]

  • HRP

    HRP Anti-Geminin antibody [EPR23754-87]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Geminin antibody [EPR23754-87]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Geminin antibody [EPR23754-87]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Geminin antibody [EPR23754-87]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Geminin antibody [EPR23754-87]

  • Unconjugated

    Anti-Geminin antibody [EPR23754-87]

  • 578 PE

    PE Anti-Geminin antibody [EPR23754-87]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Geminin antibody [EPR23754-87]

  • Carrier free

    Anti-Geminin antibody [EPR23754-87] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR23754-87

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Geminin also referred to as GMNN is a protein that regulates DNA replication. It has approximately 25 kDa mass. Geminin inhibits DNA replication by preventing the loading of the mini-chromosome maintenance complex onto DNA during the cell cycle. This function ensures that DNA replication takes place only once per cell cycle. Geminin expresses mainly in tissues with high proliferative activity such as the developing nervous system and hematopoietic cells. Its interaction with other proteins plays a significant role in controlling cell cycle progression.
Biological function summary

In a cellular context Geminin forms part of a complex with the nuclear protein Cdt1. This complex is essential in the regulation of the cell cycle's S phase. Geminin's function restricts DNA replication by binding to Cdt1 and stopping its activity which is necessary during the G1/S phase transition. By doing so it preserves the integrity of genetic information and prevents re-replication. Geminin's inhibition remains strict until it is degraded during mitosis allowing Cdt1 to resume its function in the following cell cycle.

Pathways

The regulation of Geminin is important to maintaining proper DNA replication and cell cycle integrity. Geminin plays a role in the cell cycle control pathway particularly during the G1 to S phase transition. Additionally it interfaces with other proteins like Paxillin which is involved in cell adhesion and movement. Although not directly linked in a pathway Paxillin's role in regulating cellular dynamics can influence cell cycle processes in which Geminin is involved. Geminin also serves as a K blocker relevant in maintaining genetic stability.

Aberrations in Geminin activity can lead to severe conditions such as cancer. Its overexpression or misregulation has a link to various tumor types due to its effect on uncontrolled cell proliferation. Geminin's interaction with proteins like Paxillin and Cyclin-dependent kinases also relates to cancer progression as these interactions may involve changes in cellular adhesion and cycle checkpoints. Therefore understanding Geminin's role offers valuable insight for potential therapeutic targets in oncology.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC) (PubMed : 12192004, PubMed : 9635433). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle (PubMed : 12192004, PubMed : 9635433). Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing (By similarity). Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control (By similarity).
See full target information Gmnn
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB273633

Anti-Geminin antibody [EPR23754-87] - BSA and Azide free

primary-antibodies

geminin-antibody-epr23754-87-bsa-and-azide-free-ab273633

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