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AB312951

Alexa Fluor® 568 Anti-Galactosidase alpha 抗体 [EP5828(2)]

Alexa Fluor® 568 Anti-Galactosidase alpha antibody [EP5828(2)]

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Rabbit Recombinant Monoclonal Galactosidase alpha antibody - conjugated to Alexa Fluor® 568.

別名を表示する

Alpha-galactosidase A, Alpha-D-galactosidase A, Alpha-D-galactoside galactohydrolase, Galactosylgalactosylglucosylceramidase GLA, Melibiase, GLA

関連する標識済み抗体及び組成の異なる製品 (9)

  • Unconjugated

    Anti-Galactosidase alpha antibody [EP5828(2)]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-Galactosidase alpha antibody [EP5828(2)]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Galactosidase alpha antibody [EP5828(2)]

  • 660 APC

    APC Anti-Galactosidase alpha antibody [EP5828(2)]

  • 578 PE

    PE Anti-Galactosidase alpha antibody [EP5828(2)]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Galactosidase alpha antibody [EP5828(2)]

  • Carrier free

    Anti-Galactosidase alpha antibody [EP5828(2)] - BSA and Azide free

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Galactosidase alpha antibody [EP5828(2)]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Galactosidase alpha antibody [EP5828(2)]

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EP5828(2)

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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下記製品にもご興味をお持ちいただけるかもしれません:

AB239716

Alpha Galactosidase Activity Assay Kit

0

0 Reviews

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こちらの製品も推奨する理由

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Alpha-galactosidase also known as alpha-D-galactosidase or A-galactosidase is an enzyme that catalyzes the hydrolysis of terminal alpha-galactosyl moieties from glycolipids and glycoproteins. It has a molecular mass of approximately 50000 Daltons. This enzyme is expressed in various tissues including the liver heart and kidneys. It functions by efficiently removing alpha-galactose residues from target molecules a process important for maintaining cellular function.
Biological function summary

The role of alpha-galactosidase involves the breakdown of complex carbohydrates particularly those containing alpha-galactosidic bonds. It does not operate as part of a complex but rather functions independently to cleave these specific bonds in glycolipids and glycoproteins. This activity is critical for degrading langerin and other gangliosides preventing the accumulation of these molecules in the lysosomes. By continuously performing this function alpha-galactosidase maintains glycosphingolipid homeostasis ensuring efficient cellular metabolism.

Pathways

The involvement of alpha-galactosidase in metabolic and lysosomal catabolic pathways is significant. One critical pathway is the glycolipid metabolism pathway where it acts alongside related enzymes such as beta-galactosidase. It also participates in the lysosomal degradation pathway working in conjunction with other lysosomal enzymes to prevent substrate buildup. The interaction with enzymes like lysosomal hydrolases ensures the proper breakdown of complex molecules into simpler ones that cells can utilize or excrete.

Defects in the alpha-galactosidase enzyme lead to the lysosomal storage disorder known as Fabry disease. This genetic disorder causes the accumulation of globotriaosylceramide due to deficient alpha-galactosidase activity. Another disorder associated with malfunctioning alpha-galactosidase is cardiac complications due to tissue storage of glycolipids. In both cases the lack of enzyme activity disrupts cellular and tissue functions linking alpha-galactosidase to clinical symptoms seen in these disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.
See full target information GLA
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