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AB312694

Alexa Fluor® 568 Anti-ERO1L 抗体 [EPR12474]

Alexa Fluor® 568 Anti-ERO1L antibody [EPR12474]

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Rabbit Recombinant Monoclonal ERO1L antibody - conjugated to Alexa Fluor® 568.

別名を表示する

ERO1L, UNQ434/PRO865, ERO1A, ERO1-like protein alpha, ERO1-L, ERO1-L-alpha, Endoplasmic oxidoreductin-1-like protein, Endoplasmic reticulum oxidoreductase alpha, Oxidoreductin-1-L-alpha

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-ERO1L antibody [EPR12474]

  • 578 PE

    PE Anti-ERO1L antibody [EPR12474]

  • 660 APC

    APC Anti-ERO1L antibody [EPR12474]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-ERO1L antibody [EPR12474]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-ERO1L antibody [EPR12474]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-ERO1L antibody [EPR12474]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-ERO1L antibody [EPR12474]

  • HRP

    HRP Anti-ERO1L antibody [EPR12474]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-ERO1L antibody [EPR12474]

  • Carrier free

    Anti-ERO1L antibody [EPR12474] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR12474

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ERO1L also known as ERO1-alpha is a protein involved in the formation of disulfide bonds in the endoplasmic reticulum important for protein folding. The molecular mass of ERO1L is approximately 54 kDa. ERO1L primarily expresses in tissues with high secretory activities such as the liver and pancreas. It plays a vital role in maintaining redox homeostasis within the cell by transferring electrons from protein disulfide isomerase to molecular oxygen.
Biological function summary

ERO1L contributes to oxidative protein folding within the endoplasmic reticulum. As part of a complex it interacts with protein disulfide isomerases to facilitate the introduction of disulfide bonds into nascent proteins. This function is essential for the proper maturation of secreted proteins influencing cellular protein management processes. ERO1L activity impacts cellular responses to stress and influences the capacity of cells to handle unfolded proteins.

Pathways

ERO1L significantly influences the protein folding and endoplasmic reticulum-associated degradation pathway. It has strong associations with protein disulfide isomerase and interacts within the unfolded protein response to manage cellular stress caused by misfolded proteins. The protein contributes to the maintenance of a stable internal environment during conditions where protein folding demands increase.

ERO1L shows connections to cancer and neurodegenerative disorders. Aberrant expression of ERO1L can influence tumor growth due to its role in modulating cellular stress responses and managing protein folding in cancer cells. The protein also shows a relationship with neurodegenerative conditions through its involvement in protein misfolding pathways which are critical in diseases like Alzheimer's. ERO1L collaborates with proteins like protein disulfide isomerase and participates in cellular mechanisms underlying these conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Oxidoreductase involved in disulfide bond formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI, the enzyme catalyzing protein disulfide formation, in order to allow P4HB to sustain additional rounds of disulfide formation. Following P4HB reoxidation, passes its electrons to molecular oxygen via FAD, leading to the production of reactive oxygen species (ROS) in the cell. Required for the proper folding of immunoglobulins (PubMed : 29858230). Plays an important role in ER stress-induced, CHOP-dependent apoptosis by activating the inositol 1,4,5-trisphosphate receptor IP3R1. Involved in the release of the unfolded cholera toxin from reduced P4HB/PDI in case of infection by V.cholerae, thereby playing a role in retrotranslocation of the toxin.
See full target information ERO1A
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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB249941

Anti-ERO1L antibody [EPR12474] - BSA and Azide free

primary-antibodies

ero1l-antibody-epr12474-bsa-and-azide-free-ab249941

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