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AB312447

Alexa Fluor® 568 Anti-DLL3 抗体 [EPR22592-18]

Alexa Fluor® 568 Anti-DLL3 antibody [EPR22592-18]

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Rabbit Recombinant Monoclonal DLL3 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

Delta-like protein 3, Drosophila Delta homolog 3, Delta3, DLL3

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-DLL3 antibody [EPR22592-18]

  • 578 PE

    PE Anti-DLL3 antibody [EPR22592-18]

  • 660 APC

    APC Anti-DLL3 antibody [EPR22592-18]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-DLL3 antibody [EPR22592-18]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-DLL3 antibody [EPR22592-18]

  • HRP

    HRP Anti-DLL3 antibody [EPR22592-18]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-DLL3 antibody [EPR22592-18]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-DLL3 antibody [EPR22592-18]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-DLL3 antibody [EPR22592-18]

  • Carrier free

    Anti-DLL3 antibody [EPR22592-18] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR22592-18

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

The mouse recommendation is based on the IHC-P results. We do not guarantee WB for mouse.

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下記製品にもご興味をお持ちいただけるかもしれません:

AB300312

Human DLL3 ELISA Kit

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0 Reviews

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こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

お客様の実験に適するかご確認いただくため、必ず製品データシートをご確認いただくことをお勧めいたします。ご不明点等ございましたら、テクニカルサポートチームまでお問い合わせください。

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製品の詳細

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

DLL3 also known as Delta-like protein 3 is a member of the Delta/Serrate/Jagged family. This protein has a molecular mass of approximately 64 kDa. Scientists find DLL3 expression primarily in the Golgi apparatus of cells. In healthy tissues DLL3 is mostly present in the central nervous system whereas in abnormal conditions it appears in certain types of cancer cells. The detection of DLL3 expression commonly performed using IHC (immunohistochemistry) highlights its potential as a biomarker in pathological studies.
Biological function summary

DLL3 functions mainly in the modulation of the Notch signaling pathway. It does not activate this pathway but acts as an inhibitor blocking Notch ligand activation on adjacent cells. DLL3's role involves binding directly to Notch receptors altering cellular differentiation and growth processes. Despite being related to the Delta/Serrate/LAG-2 family DLL3 exhibits unique characteristics in its interactions forming part of a regulatory complex different from its family members.

Pathways

DLL3 engages importantly in the Notch signaling pathway affecting important cellular communications that regulate development and differentiation. Its interaction with proteins of the Notch family specifically the Notch receptors highlights its inhibitory role. Additionally DLL3 intersects with the Wnt signaling pathway though indirect influencing its output by modulating availability of pathway regulators.

DLL3 has significant implications in cancer notably small cell lung cancer (SCLC) and neuroendocrine tumors. Researchers associate increased DLL3 expression with aggressive tumor behavior and poor prognosis. The protein also shows relevance in congenital disorders such as spondylocostal dysostosis where abnormal DLL3 function leads to vertebral segmentation defects. In these contexts DLL3 often relates to proteins involved in the disruption of normal signaling cascades impacting both tumor progression and developmental anomalies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
See full target information DLL3
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB255694

Anti-DLL3 antibody [EPR22592-18] - BSA and Azide free

primary-antibodies

dll3-antibody-epr22592-18-bsa-and-azide-free-ab255694

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(0 reviews)

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