JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB312641

Alexa Fluor® 568 Anti-CHD3 抗体 [EPNCIR110A]

Alexa Fluor® 568 Anti-CHD3 antibody [EPNCIR110A]

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Recombinant Monoclonal CHD3 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

2600010P09Rik, AF020312, ATP-dependent helicase Chd3, CHD3_HUMAN, Chromodomain-helicase-DNA-binding protein 3, MGC40857, Mi 2a, Mi-2 autoantigen 240 kDa protein, Mi2-alpha, Prp7, Prp9 1, ZFH, Zinc finger helicase, hZFH, zinc-finger helicase (Snf2-like)

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-CHD3 antibody [EPNCIR110A]

  • 660 APC

    APC Anti-CHD3 antibody [EPNCIR110A]

  • HRP

    HRP Anti-CHD3 antibody [EPNCIR110A]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-CHD3 antibody [EPNCIR110A]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-CHD3 antibody [EPNCIR110A]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-CHD3 antibody [EPNCIR110A]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-CHD3 antibody [EPNCIR110A]

  • 578 PE

    PE Anti-CHD3 antibody [EPNCIR110A]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-CHD3 antibody [EPNCIR110A]

  • Carrier free

    Anti-CHD3 antibody [EPNCIR110A] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPNCIR110A

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Antibody Labelling, Target Binding Affinity

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

style
left-column
style
left-column

製品の詳細

style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CHD3 also known as Chromodomain Helicase DNA Binding Protein 3 is a protein involved in transcription regulation. The protein has a molecular mass of approximately 220 kDa. CHD3 is a member of the chromatin remodeler family and is expressed widely throughout various tissues. It contains dual chromodomains a helicase/ATPase domain and a DNA-binding domain enabling it to remodel chromatin structure by altering nucleosome positioning on DNA.
Biological function summary

CHD3 plays a significant role in modifying chromatin architecture and regulating the accessibility of the DNA to transcription factors. It functions as part of the NuRD (Nucleosome Remodeling and Deacetylase) complex which combines the features of ATP-dependent chromatin remodeling and histone deacetylase activity. CHD3 helps remodel nucleosomes and remove acetyl groups from histones which leads to chromatin condensation and transcriptional repression. Its activity influences genes involved in development differentiation and cell cycle control.

Pathways

CHD3's function integrates into pathways that control gene expression and DNA repair. It plays a role in the transcriptional regulation pathway working alongside proteins like HDAC1 and NuRD components. Additionally CHD3 participates in the DNA damage response cooperating with proteins such as CHD4 and RBBP4 to ensure genomic stability. These interactions and functions place CHD3 at a strategic position within cellular mechanisms maintaining transcription fidelity and genomic integrity.

CHD3 associations with cancer and developmental disorders stand out. Abnormal expression or mutations in CHD3 can contribute to tumorigenesis as it can affect the expression and repression of oncogenes and tumor suppressor genes. Furthermore CHD3 mutations have been linked to Snijders Blok-Campeau syndrome a neurodevelopmental disorder. The interaction between CHD3 and other proteins like HDAC1 and CHD4 plays a critical role in the manifestation of these conditions influencing pathways that drive disease progression and phenotype expression.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

See full target information CHD3
style
left-column
style
left-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。
style
left-column
style
right-column

関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB240942

Anti-CHD3 antibody [EPNCIR110A] - BSA and Azide free

primary-antibodies

chd3-antibody-epncir110a-bsa-and-azide-free-ab240942

0

(0 reviews)

style
bg-slate-100

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com