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AB312475

Alexa Fluor® 568 Anti-CCT2 抗体 [EPR4084]

Alexa Fluor® 568 Anti-CCT2 antibody [EPR4084]

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Rabbit Recombinant Monoclonal CCT2 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

99D8.1, CCTB, CCT2, T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, Chaperonin containing T-complex polypeptide 1 subunit 2

関連する標識済み抗体及び組成の異なる製品 (10)

  • Unconjugated

    Anti-CCT2 antibody [EPR4084]

  • 578 PE

    PE Anti-TCP1 beta antibody [EPR4084]

  • 660 APC

    APC Anti-TCP1 beta antibody [EPR4084]

  • HRP

    HRP Anti-TCP1 beta antibody [EPR4084]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-TCP1 beta antibody [EPR4084]

  • 565 Alexa Fluor® 555

    Alexa Fluor® 555 Anti-TCP1 beta antibody [EPR4084]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-TCP1 beta antibody [EPR4084]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-TCP1 beta antibody [EPR4084]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-CCT2 antibody [EPR4084]

  • Carrier free

    Anti-CCT2 antibody [EPR4084] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR4084

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CCT2 also known as Chaperonin Containing TCP1 Subunit 2 is part of a group of proteins responsible for facilitating the correct folding of other proteins. It functions as a molecular chaperone and has a molecular weight of approximately 58 kDa. CCT2 is expressed in many tissues with high levels detected in testis and brain tissues. This protein is integral to the chaperonin CCT (or TRiC) complex contributing to essential cellular processes through its role in protein homeostasis.
Biological function summary

CCT2 assists in the folding of cytoskeletal proteins like actin and tubulin which are vital for maintaining the structure and function of cells. As part of the CCT complex which consists of eight different subunits CCT2 plays a significant role in ensuring the proper assembly of multi-protein complexes. The activity of CCT2 is important for the prevention of aggregate formation which otherwise leads to cellular stress.

Pathways

CCT2 significantly influences the protein folding and degradation pathways. It participates in the cellular pathways that govern the proteostasis network collaborating with other chaperones to oversee protein quality control. Related proteins interacting with CCT2 within these pathways include other CCT complex components like CCT3 and CCT4 all contributing to maintaining cellular homeostasis and protecting cells from proteotoxic damage.

CCT2 is connected to cancer and neurodegenerative diseases. Altered expression of CCT2 is linked to the progression of tumor growth interacting with proteins involved in cell cycle regulation and signaling such as p53. Additionally deficits in CCT2 function can exacerbate protein misfolding disorders like Alzheimer's disease where proteins like tau become aggregated contributing to the pathology. Efforts to understand CCT2's role in these conditions highlight the importance of protein homeostasis in maintaining health.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed : 25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed : 25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed : 20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable).
See full target information CCT2
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB247598

Anti-CCT2 antibody [EPR4084] - BSA and Azide free

primary-antibodies

cct2-antibody-epr4084-bsa-and-azide-free-ab247598

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