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AB312611

Alexa Fluor® 568 Anti-Anterior Gradient 2 抗体 [EPR3278]

Alexa Fluor® 568 Anti-Anterior Gradient 2 antibody [EPR3278]

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Rabbit Recombinant Monoclonal Anterior Gradient 2 antibody - conjugated to Alexa Fluor® 568.

別名を表示する

AG2, UNQ515/PRO1030, AGR2, Anterior gradient protein 2 homolog, AG-2, hAG-2, HPC8, Secreted cement gland protein XAG-2 homolog

関連する標識済み抗体及び組成の異なる製品 (9)

  • Unconjugated

    Anti-Anterior Gradient 2 antibody [EPR3278]

  • 660 APC

    APC Anti-Anterior Gradient 2 antibody [EPR3278]

  • HRP

    HRP Anti-Anterior Gradient 2 antibody [EPR3278]

  • 578 PE

    PE Anti-Anterior Gradient 2 antibody [EPR3278]

  • 617 Alexa Fluor® 594

    Alexa Fluor® 594 Anti-Anterior Gradient 2 antibody [EPR3278]

  • 665 Alexa Fluor® 647

    Alexa Fluor® 647 Anti-Anterior Gradient 2 antibody [EPR3278]

  • 775 Alexa Fluor® 750

    Alexa Fluor® 750 Anti-Anterior Gradient 2 antibody [EPR3278]

  • 519 Alexa Fluor® 488

    Alexa Fluor® 488 Anti-Anterior Gradient 2 antibody [EPR3278]

  • Carrier free

    Anti-Anterior Gradient 2 antibody [EPR3278] - BSA and Azide free

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR3278

アイソタイプ

IgG

標識

Alexa Fluor® 568

励起波長/蛍光波長

Ex: 578nm, Em: 603nm

キャリアフリー

No

アプリケーション

Target Binding Affinity, Antibody Labelling

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Human AG-2 ELISA Kit

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こちらの製品も推奨する理由

この製品は、同様の実験や関連する研究で広く使用されていることから推奨させていただいております。

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製品の詳細

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

How are conjugated primary antibodies validated?
This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.
For suitable applications and species reactivity, please refer to the unconjugated version of this clone.

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle|Store in the dark

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Anterior Gradient 2 (AG2) also known as AGR2 is a protein with a molecular weight of approximately 20 kDa. This protein is a member of the protein disulfide isomerase family and has an important mechanical role in facilitating protein folding within the endoplasmic reticulum. The protein exists mainly in epithelial tissues and notably in the gastrointestinal tract with high expression also found in the pancreas and lungs. AG2 is characterized by its interaction with various client proteins assisting in their proper folding and stability.
Biological function summary

The anterior gradient protein influences cellular processes such as proliferation and differentiation often playing a role in cellular adhesion and migration. This protein does not work alone but instead can form complexes with other molecules enhancing its functional capabilities. Such interactions highlight its significance in maintaining normal cell physiology and response to external stimuli.

Pathways

Anterior gradient protein participates in key signaling pathways including the Wnt signaling pathway and the unfolded protein response (UPR). Through these pathways AG2 associates with proteins like β-catenin influencing gene transcription and cellular outcomes. In the UPR its role is important in managing cellular stress and maintaining homeostasis by regulating protein folding and quality control mechanisms.

Anterior gradient protein shows strong associations with cancer particularly in tumors such as breast and lung cancer where it is often overexpressed. Its involvement links closely with proteins like MUC1 which is found in tumors suggesting a role in promoting cancer progression and metastasis. Additionally AG2 can be related to inflammatory bowel diseases where its dysregulation may result in epithelial barrier dysfunction and contribute to the pathology.

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

ターゲットの情報

Required for MUC2 post-transcriptional synthesis and secretion. May play a role in the production of mucus by intestinal cells (By similarity). Proto-oncogene that may play a role in cell migration, cell differentiation and cell growth. Promotes cell adhesion (PubMed : 23274113).
See full target information AGR2

Abcam product promise

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保証に関する詳細については利用規約をご確認ください。

関連製品

Select an associated product type
Alternative Version
Primary Antibodies

AB181829

Anti-Anterior Gradient 2 antibody [EPR3278] - BSA and Azide free

primary-antibodies

anterior-gradient-2-antibody-epr3278-bsa-and-azide-free-ab181829

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